PMID- 33602086
OWN - NLM
STAT- MEDLINE
DCOM- 20211116
LR  - 20221207
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 17
IP  - 13
DP  - 2020
TI  - Association of Red Blood Cell Indices with Mild Cognitive Impairment in Chinese 
      Elderly Individuals: A Matched Case-control Study.
PG  - 1161-1166
LID - 10.2174/1567205018666210218144856 [doi]
AB  - BACKGROUND: Mild cognitive impairment (MCI) represents an intermediate and 
      modifiable stage between normal aging and dementia. There is an urgent need for 
      simple, non-invasive testing of MCI by blood biomarkers. OBJECTIVE: This study 
      aimed to retrospectively evaluate the association of red blood cell (RBC) indices 
      with MCI, and select the best hematologic characteristic for detection of MCI in 
      elderly Chinese. METHODS: Matched case-control study was carried out with 85 
      pairs of MCI subjects and healthy controls. The matching criteria was age, gender 
      and education attainment. All samples were analyzed for RBC indices, including 
      hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean 
      corpuscular hemoglobin concentration (MCHC) and red cell distribution 
      width-standard deviation (RDW-SD). A conditional logistic regression model was 
      used to evaluate the association between RBC indices and MCI. The diagnostic 
      efficacy of the biomarkers was evaluated by receiver operating characteristics 
      (ROC). RESULTS: Among all RBC indices, there were significant differences in HGB 
      (124.82 +/- 7.89 vs. 133.93 +/- 4.52, P < 0.001) and RDW-SD (45.29 +/- 2.03 vs. 41.34 +/- 
      4.41, P < 0.001) between two groups. In the logistic regression model, after 
      adjustment for lifestyle factors and comorbidities, significant statistically 
      associations have been found between higher HGB and lower risk of MCI (adjusted 
      OR: 0.831; 95% CI: 0.773-0.893), higher RDW-SD and a higher risk of MCI (adjusted 
      OR: 1.575; 95% CI: 1.326- 1.872). ROC analysis suggested that the largest area 
      under the ROC curve (AUC) was found with the combination of HGB and RDW-SD (AUC = 
      0.842), followed by HGB(AUC = 0.795), and finally by modest RDW-SD (AUC = 0.777). 
      Combination of HGB <131 g/L and RDW-SD >43.4 fL yielded a sensitivity of 92% and 
      a specificity of 89%, overall diagnosis efficiency of which were better than HBG 
      and RDW-SD alone. CONCLUSION: Lower HGB and higher RDW-SD alone were 
      significantly found to be associated with increased risk of MCI, and offered 
      modest sensitivity and specificity as a diagnostic marker. The combination of HGB 
      and RDW-SD was more sensitive and had higher classification accuracy for 
      differentiating MCI from healthy controls. Further prospective research is needed 
      to clarify whether HGB in combination with RDW-SD may be a potential diagnostic 
      tool for early diagnosis of AD.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Du, Yue
AU  - Du Y
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Jin, Mengdi
AU  - Jin M
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Liu, Qian
AU  - Liu Q
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Zhao, Jiangang
AU  - Zhao J
AD  - Sanhuailu Street Community Health Service Center of Binhai New Area, Tianjin, 
      China.
FAU - Song, Aili
AU  - Song A
AD  - Sanhuailu Street Community Health Service Center of Binhai New Area, Tianjin, 
      China.
FAU - Li, Wen
AU  - Li W
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Rehabilitation Medicine, Tianjin Medical University, Tianjin, 
      China.
FAU - Ma, Fei
AU  - Ma F
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
FAU - Huang, Guowei
AU  - Huang G
AD  - Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Biomarkers)
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Aged
MH  - Asian People/*statistics & numerical data
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - China
MH  - *Cognitive Dysfunction/blood
MH  - *Erythrocyte Indices
MH  - Female
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Male
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Mild cognitive impairment
OT  - ROC curve
OT  - biomarker
OT  - dementia
OT  - elderly
OT  - matched case-control study
EDAT- 2021/02/20 06:00
MHDA- 2021/11/17 06:00
CRDT- 2021/02/19 05:40
PHST- 2019/11/23 00:00 [received]
PHST- 2020/10/12 00:00 [revised]
PHST- 2020/12/27 00:00 [accepted]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/11/17 06:00 [medline]
PHST- 2021/02/19 05:40 [entrez]
AID - CAR-EPUB-114339 [pii]
AID - 10.2174/1567205018666210218144856 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2020;17(13):1161-1166. doi: 
      10.2174/1567205018666210218144856.