PMID- 33602121
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20231110
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Feb 18
TI  - Hyperhomocysteinemia and its relations to conventional risk factors for 
      cardiovascular diseases in adult Nigerians: the REMAH study.
PG  - 102
LID - 10.1186/s12872-021-01913-x [doi]
LID - 102
AB  - BACKGROUND: Evidence linking homocysteine (Hcy) with cardiovascular diseases 
      (CVD) or its risk factors are limited in a sub-Saharan black population. 
      OBJECTIVE: We set out to evaluate the association between Hcy and hypertension 
      and other CVD risk factors in a population of adult Nigerians. METHODS: Data of 
      156 adults aged 18-70 years was accessed from the North Central study site of the 
      REmoving the MAsk on Hypertension (REMAH) study. Homocysteine, blood glucose and 
      lipid profile in whole blood/serum were measured using standard laboratory 
      methods. Hypertension was diagnosed if average of 5 consecutive blood pressure 
      (BP) measurements obtained using a mercury sphygmomanometer was equal to or 
      higher than 140 systolic and/or 90 mmHg diastolic or the individual is on 
      antihypertensive medication. Hyperhomocysteinemia (HHcy) was defined as 
      Hcy > 10 micromol/L. RESULTS: Of the 156 participants, 72 (43.5%) were hypertensive, 
      of whom 18 had HHcy. Subjects with HHcy were significantly (p < 0.05) older (41.5 
      vs. 40.6yrs), had lower HDL-cholesterol (0.6 vs. 0.8 mmol/L) and higher systolic 
      (145.5 vs. 126.0 mmHg) and diastolic BP (92.9 vs. 79.6 mmHg), compared to those 
      without HHcy. Intake of alcohol and a 1 yr increase in age were respectively and 
      significantly (p < 0.05) associated with a 1.54 and 0.10 micromol/L increase in Hcy. 
      In a multivariable model adjusted for age, sex and body mass index, a 1 micromol/L 
      increase in Hcy, was associated with a 1.69 mmHg and 1.34 mmHg increase in 
      systolic and diastolic pressure (p < 0.0001) respectively; and a 0.01 mmol/L 
      decrease in HDL-cholesterol (p < 0.05). CONCLUSION: HHcy occurs among 
      hypertensive Nigerians and it is independently associated with age, 
      HDL-cholesterol, systolic and diastolic BP.
FAU - Chori, Babangida S
AU  - Chori BS
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Health Sciences, University of Abuja, Abuja, Nigeria.
AD  - Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of 
      Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, 
      Nigeria.
FAU - Danladi, Benjamin
AU  - Danladi B
AD  - Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of 
      Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, 
      Nigeria.
FAU - Inyang, Bassey A
AU  - Inyang BA
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Health Sciences, University of Abuja, Abuja, Nigeria.
FAU - Okoh, Michael P
AU  - Okoh MP
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Health Sciences, University of Abuja, Abuja, Nigeria.
FAU - Nwegbu, Maxwell M
AU  - Nwegbu MM
AD  - Department of Chemical Pathology, College of Health Sciences, Faculty of Basic 
      Clinical Sciences, University of Abuja, Abuja, Nigeria.
FAU - Alli, Adewale L
AU  - Alli AL
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Health Sciences, University of Abuja, Abuja, Nigeria.
FAU - Odili, Augustine N
AU  - Odili AN
AD  - Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of 
      Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, 
      Nigeria. augustine.odili@uniabuja.edu.ng.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210218
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Black People
MH  - Blood Pressure
MH  - Cardiovascular Diseases/blood/diagnosis/*epidemiology
MH  - Cholesterol, HDL/blood
MH  - Dyslipidemias/blood/diagnosis/epidemiology
MH  - Heart Disease Risk Factors
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnosis/*epidemiology
MH  - Hypertension/diagnosis/epidemiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Risk Assessment
MH  - Young Adult
PMC - PMC7890880
OTO - NOTNLM
OT  - Blood pressure
OT  - Cardiovascular diseases risk factors
OT  - High-density lipoprotein
OT  - Hyperhomocysteinemia
COIS- None of the authors declares a conflict of interest.
EDAT- 2021/02/20 06:00
MHDA- 2021/10/05 06:00
PMCR- 2021/02/18
CRDT- 2021/02/19 05:40
PHST- 2020/11/24 00:00 [received]
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/02/19 05:40 [entrez]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/02/18 00:00 [pmc-release]
AID - 10.1186/s12872-021-01913-x [pii]
AID - 1913 [pii]
AID - 10.1186/s12872-021-01913-x [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2021 Feb 18;21(1):102. doi: 10.1186/s12872-021-01913-x.