PMID- 33603421
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and 
      Obesity in Korean Patients with Type 2 Diabetes Mellitus.
PG  - 557-564
LID - 10.2147/DMSO.S293032 [doi]
AB  - BACKGROUND: Vitamin D receptor (VDR) polymorphisms are associated with 
      osteoporosis, diabetes, immunological diseases, and cancers. However, the 
      association of obesity with VDR polymorphisms has shown inconsistent results, and 
      perhaps it depends upon the characteristics of a population. Therefore, we 
      evaluated the association between BsmI (rs1544410) and ApaI (rs7975232) 
      polymorphisms of VDR and obesity in Korean patients with type 2 diabetes mellitus 
      (T2DM). METHODS: A total of 506 patients with T2DM participated in the study. 
      Polymerase chain reaction-restriction fragment length polymorphism was used to 
      analyze BsmI and ApaI polymorphisms; the genotypes were presented as BB, Bb, or 
      bb for BsmI and AA, Aa, or aa for ApaI. Obesity was defined using the body mass 
      index (BMI) with a cutoff level of 25 kg/m(2). RESULTS: The prevalence of obesity 
      was higher in patients with the bb genotype than in those with BB or Bb genotypes 
      (48.4% vs 33.9%, P = 0.031). The mean BMI was 25.2 +/- 3.5 kg/m(2) in patients with 
      bb genotype and 24.1 +/- 3.1 kg/m(2) in patients with BB or Bb genotypes. Patients 
      with Aa or aa genotypes showed a higher prevalence of obesity than patients with 
      AA genotype (47.6% vs 26.1%, P = 0.043). Glycemic control parameters and lipid 
      profiles did not show significant differences with either polymorphism. 
      CONCLUSION: To our knowledge, this is the first study to assess the association 
      between VDR polymorphisms and obesity in Korean patients with T2DM. Further 
      studies in larger populations and multiethnic cohorts are needed to validate our 
      findings.
CI  - (c) 2021 Nam et al.
FAU - Nam, Sang Won
AU  - Nam SW
AD  - Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, 
      South Korea.
FAU - Choi, Jinwoo
AU  - Choi J
AD  - Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, 
      South Korea.
FAU - Jeon, Hyun Jeong
AU  - Jeon HJ
AD  - Department of Internal Medicine, Chungbuk National University College of 
      Medicine, Cheongju, South Korea.
FAU - Oh, Tae Keun
AU  - Oh TK
AD  - Department of Internal Medicine, Chungbuk National University College of 
      Medicine, Cheongju, South Korea.
FAU - Lee, Dong-Hwa
AU  - Lee DH
AUID- ORCID: 0000-0002-1552-3205
AD  - Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, 
      South Korea.
LA  - eng
PT  - Journal Article
DEP - 20210210
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7882455
OTO - NOTNLM
OT  - obesity
OT  - polymorphism
OT  - type 2 diabetes mellitus
OT  - vitamin D
OT  - vitamin D receptor gene
COIS- The authors received no funding and report no conflicts of interest for this 
      work.
EDAT- 2021/02/20 06:00
MHDA- 2021/02/20 06:01
PMCR- 2021/02/10
CRDT- 2021/02/19 06:04
PHST- 2020/12/01 00:00 [received]
PHST- 2021/01/27 00:00 [accepted]
PHST- 2021/02/19 06:04 [entrez]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/02/20 06:01 [medline]
PHST- 2021/02/10 00:00 [pmc-release]
AID - 293032 [pii]
AID - 10.2147/DMSO.S293032 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Feb 10;14:557-564. doi: 10.2147/DMSO.S293032. 
      eCollection 2021.