PMID- 33603637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 1658-3612 (Electronic)
IS  - 1658-3612 (Linking)
VI  - 16
IP  - 1
DP  - 2021 Feb
TI  - Nutritional modulation of blood pressure and vascular changes during severe 
      menstrual cramps.
PG  - 93-101
LID - 10.1016/j.jtumed.2020.10.018 [doi]
AB  - OBJECTIVES: This study examined the influence of nutrition on the severity of 
      menstrual pains and associated transient changes in blood pressure (BP) and 
      vascular-health indicators. It has also investigated the influence of nutrition 
      on angiotensin (ANG II) and vascular cell adhesion molecules (VCAM-1). METHODS: A 
      total of 207 university students, aged between 18 and 25 years, were grouped into 
      three groups: a no-dysmenorrhoea (control) group, a moderate dysmenorrhoea (MDys) 
      group, and a severe dysmenorrhoea (SDys) group, using the NRS-11 scale and 
      initial contactin-1 (CNTN-1) levels. The groups were separately fed vegetable, 
      protein, and carbohydrate meals. The meal plan involved three different types of 
      food served three times a day (for breakfast, lunch, and dinner), beginning 
      48 h before menstruation. RESULTS: We found that 73.9% and 100% of the MDys 
      patients on the protein and carbohydrate diets, respectively, had severe 
      dysmenorrhoea. As many as 69.6% of the SDys patients on vegetable diets 
      experienced no dysmenorrhoea; the BP of 61% of SDys normalised to the standard 
      values of 120/80. The BP of 87% MDys had systolic BP >/= 130 and >/=90 diastolic BP 
      after carbohydrate meals. On the other hand, 30% of SDys had higher BP after 
      protein meals. With respect to the choice of food, the severity of menstrual pain 
      was positively correlated with ANG II (r = 0.5158) and VCAM-1 (r = 0.5849). 
      ANG-II. Similarly, VCAM-1 were significantly elevated (p < 0.05) in the 
      dysmenorrhoeal participants. The mean VCAM-1 and ANG-II levels of dysmenorrhoeal 
      participants placed on vegetable meals were comparable to the control baseline 
      levels. CONCLUSIONS: This study recommends the intake of a vegetable meal at 
      least 48 h before menstruation as an effective nutritional approach to preventing 
      and managing severe menstrual cramps. This approach can also prevent associated 
      vascular changes. Carbohydrate meals should be avoided at least 48 h before 
      menstruation.
CI  - (c) 2020 The Authors.
FAU - Njoku, Uche C
AU  - Njoku UC
AD  - Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, 
      Nigeria.
FAU - Amadi, Peter U
AU  - Amadi PU
AD  - Department of Biochemistry, Imo State University Owerri, Imo State, Nigeria.
FAU - Amadi, Joy A
AU  - Amadi JA
AD  - Department of Nutrition and Dietetics, Imo State University Owerri, Imo State, 
      Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20201127
PL  - Saudi Arabia
TA  - J Taibah Univ Med Sci
JT  - Journal of Taibah University Medical Sciences
JID - 101621911
PMC - PMC7858019
OTO - NOTNLM
OT  - Blood pressure
OT  - Dysmenorrhoea
OT  - Nutrition
OT  - Pain
OT  - Vascular
EDAT- 2021/02/20 06:00
MHDA- 2021/02/20 06:01
PMCR- 2020/11/27
CRDT- 2021/02/19 06:05
PHST- 2020/07/16 00:00 [received]
PHST- 2020/10/18 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2021/02/19 06:05 [entrez]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/02/20 06:01 [medline]
PHST- 2020/11/27 00:00 [pmc-release]
AID - S1658-3612(20)30170-0 [pii]
AID - 10.1016/j.jtumed.2020.10.018 [doi]
PST - epublish
SO  - J Taibah Univ Med Sci. 2020 Nov 27;16(1):93-101. doi: 
      10.1016/j.jtumed.2020.10.018. eCollection 2021 Feb.