PMID- 33603896
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210220
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 19
IP  - 2
DP  - 2021 Feb
TI  - Modification of the existing maximum residue levels for difenoconazole in leafy 
      brassica.
PG  - e06407
LID - 10.2903/j.efsa.2021.6407 [doi]
LID - e06407
AB  - In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant 
      Syngenta Crop Protection AG submitted a request to the competent national 
      authority in the Netherlands to modify the existing maximum residue levels (MRLs) 
      for the active substance difenoconazole in commodities belonging to the group of 
      leafy brassica. The data submitted in support of the request were found to be 
      sufficient to derive MRL proposals for leafy brassica. Adequate analytical 
      methods for enforcement are available to control the residues of difenoconazole 
      in plant matrices under consideration at the validated LOQ of 0.01 mg/kg and for 
      difenoconazole and metabolite CGA205375 in animal matrices at the validated LOQ 
      of 0.01 mg/kg for meat muscle, fat, liver, kidney and eggs and at the validated 
      LOQ of 0.005 mg/kg for milk. Based on the risk assessment results, EFSA concluded 
      that for the crops assessed in this application the short-term intake of residues 
      resulting from the use of difenoconazole according to the reported agricultural 
      practices is unlikely to present a risk to consumer health. Long-term consumer 
      intake concerns cannot be excluded for the intended and existing difenoconazole 
      uses as they are affected by uncertainties associated with the toxicity of 
      metabolite CGA205375 and the lack of information on all existing difenoconazole 
      uses in the EU. Overall, this risk assessment is considered provisional, pending 
      the submission of confirmatory data on possible preferential 
      metabolism/degradation of the four stereo isomers of difenoconazole in plants and 
      has to be re-considered when the missing data become available. Additionally, 
      this assessment does not take into consideration triazole derivative metabolites 
      (TDMs) which may be generated by several pesticides belonging to the group of 
      triazole fungicides as this application was submitted before September 2019 which 
      is the date of application of the new strategy endorsed by the risk managers for 
      the assessment of TDMs.
CI  - (c) 2021 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - European Food Safety Authority (EFSA)
FAU - Anastassiadou, Maria
AU  - Anastassiadou M
FAU - Bernasconi, Giovanni
AU  - Bernasconi G
FAU - Brancato, Alba
AU  - Brancato A
FAU - Carrasco Cabrera, Luis
AU  - Carrasco Cabrera L
FAU - Ferreira, Lucien
AU  - Ferreira L
FAU - Greco, Luna
AU  - Greco L
FAU - Jarrah, Samira
AU  - Jarrah S
FAU - Kazocina, Aija
AU  - Kazocina A
FAU - Leuschner, Renata
AU  - Leuschner R
FAU - Magrans, Jose Oriol
AU  - Magrans JO
FAU - Miron, Ileana
AU  - Miron I
FAU - Nave, Stefanie
AU  - Nave S
FAU - Pedersen, Ragnor
AU  - Pedersen R
FAU - Reich, Hermine
AU  - Reich H
FAU - Rojas, Alejandro
AU  - Rojas A
FAU - Sacchi, Angela
AU  - Sacchi A
FAU - Santos, Miguel
AU  - Santos M
FAU - Scarlato, Alessia Pia
AU  - Scarlato AP
FAU - Theobald, Anne
AU  - Theobald A
FAU - Vagenende, Benedicte
AU  - Vagenende B
FAU - Verani, Alessia
AU  - Verani A
LA  - eng
PT  - Journal Article
DEP - 20210209
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7871204
OTO - NOTNLM
OT  - MRL
OT  - consumer risk assessment
OT  - difenoconazole
OT  - kale
OT  - leafy brassica
OT  - pesticide
EDAT- 2021/02/20 06:00
MHDA- 2021/02/20 06:01
PMCR- 2021/02/09
CRDT- 2021/02/19 06:06
PHST- 2021/02/19 06:06 [entrez]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/02/20 06:01 [medline]
PHST- 2021/02/09 00:00 [pmc-release]
AID - EFS26407 [pii]
AID - 10.2903/j.efsa.2021.6407 [doi]
PST - epublish
SO  - EFSA J. 2021 Feb 9;19(2):e06407. doi: 10.2903/j.efsa.2021.6407. eCollection 2021 
      Feb.