PMID- 33604810
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20240402
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 476
IP  - 6
DP  - 2021 Jun
TI  - Association of macrophage inhibitory factor -1 polymorphisms with antiviral 
      efficacy of type 1b chronic hepatitis C.
PG  - 2439-2447
LID - 10.1007/s11010-021-04097-2 [doi]
AB  - The expression of macrophage inhibitory factor-1 (MIC-1) increases in patients 
      with chronic hepatitis C (CHC), but whether MIC-1 level and its polymorphism 
      affect the antiviral efficacy of CHC has not yet been reported. The present study 
      aimed to investigate the association between MIC-1 polymorphism and antiviral 
      efficacy in patients with CHC genotype 1b (CHC 1b). A total of 171 patients with 
      CHC1b were recruited. The polymorphisms of rs1059369 and rs1059519 in MIC-1 were 
      detected by DNA sequencing. All patients received a standard dose of polyethylene 
      glycol interferon + ribavirin (PR regimen), and divided into response, 
      nonresponse, sustained virological response (SVR), and non-sustained virological 
      response (NSVR) groups based on HCV RNA levels. The genotype distribution of the 
      two single nucleotide polymorphisms (SNPs) did not differ between the response 
      and nonresponse groups, SVR and non-SVR groups. However, the level of MIC-1 was 
      positively correlated with ALT, AST, PIIINP, CIV, and HCV RNA (P < 0.05). 
      Compared to before treatment, the level of MIC-1 in plasma was significantly 
      decrease in the response group but not in the non-responsive group. Our results 
      suggest that the level of MIC-1 in CHC1b is correlated with liver cell injury, 
      liver fibrosis index, and viral load. However, the polymorphism of rs1059369 and 
      rs1059519 may have negligible impact in expression of MIC-1 and efficacy of 
      antiviral therapy in CHC patient.
FAU - Ye, Songdao
AU  - Ye S
AD  - Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Chen, Yao
AU  - Chen Y
AD  - Department of Pathology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Lou, Xiaoting
AU  - Lou X
AD  - Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial 
      Key Laboratory of Medical Genetics, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Ye, Xuanmei
AU  - Ye X
AD  - Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Yang, Xunjun
AU  - Yang X
AUID- ORCID: 0000-0001-5984-1865
AD  - Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. 
      18367813521@163.com.
AD  - Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial 
      Key Laboratory of Medical Genetics, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China. 18367813521@163.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20210218
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (GDF15 protein, human)
RN  - 0 (Growth Differentiation Factor 15)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Growth Differentiation Factor 15/biosynthesis/*genetics
MH  - *Hepacivirus
MH  - Hepatitis C, Chronic/*drug therapy/*genetics/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
PMC - PMC8119258
OTO - NOTNLM
OT  - Antiviral therapy
OT  - Chronic hepatitis C
OT  - Macrophage inhibitory factor-1
OT  - Single nucleotide polymorphisms
COIS- There are no conflicts of interest.
EDAT- 2021/02/20 06:00
MHDA- 2021/07/29 06:00
PMCR- 2021/02/18
CRDT- 2021/02/19 06:11
PHST- 2020/09/02 00:00 [received]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2021/02/19 06:11 [entrez]
PHST- 2021/02/18 00:00 [pmc-release]
AID - 10.1007/s11010-021-04097-2 [pii]
AID - 4097 [pii]
AID - 10.1007/s11010-021-04097-2 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2021 Jun;476(6):2439-2447. doi: 10.1007/s11010-021-04097-2. 
      Epub 2021 Feb 18.