PMID- 33605141
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 69
IP  - 8
DP  - 2021 Mar 3
TI  - Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic 
      Mice and Its Mechanism Study.
PG  - 2444-2456
LID - 10.1021/acs.jafc.0c07630 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a type of metabolic illness based on 
      relatively insufficient insulin secretion and insulin resistance (IR) as 
      pathophysiological bases. Currently, it is the main type of diabetes. 
      Hypoglycemic and hypolipidemic effects of licochalcone A (LicA) on high-fat diet 
      and streptozocin-caused T2DM were studied. LicA can remarkably decline the IR 
      index and blood glucose and serum lipid levels. Also, the treatment of LicA can 
      improve the "three more and one less" phenomenon in T2DM mice, such as excessive 
      drinking, eating, urine, and weight loss. In addition, LicA can improve oral 
      glucose tolerance, pancreatic injury, and liver enlargement in T2DM mice. Network 
      pharmacology analysis demonstrated that the observed pharmacological effects were 
      mediated by regulating the insulin signal transduction pathway. Therefore, the 
      PI3K/Akt-signaling pathway was selected for verification; it was demonstrated 
      that LicA could improve the insulin-signaling pathway, protect islet cells, 
      improve IR, reduce blood glucose levels, and alleviate lipid metabolism disorder. 
      Its mechanism of influence may be closely related to LicA up-regulating the liver 
      and pancreas IRS-2/PI3K/AKT-signaling pathway. Among them, the high-dose group of 
      LicA had the best effect, which provided an idea for the use of LicA as a 
      nutritional agent in the cure of T2DM.
FAU - Luo, Zhonghua
AU  - Luo Z
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Fu, Chaofan
AU  - Fu C
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Li, Tao
AU  - Li T
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Gao, Qingqing
AU  - Gao Q
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Miao, Dongyu
AU  - Miao D
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Xu, Jing
AU  - Xu J
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Zhao, Yuqing
AU  - Zhao Y
AUID- ORCID: 0000-0002-8359-4830
AD  - Shenyang Pharmaceutical University, Shenyang 110016, China.
AD  - Key Laboratory of Structure-based Drug Design and Discovery of Ministry of 
      Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
LA  - eng
PT  - Journal Article
DEP - 20210219
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Blood Glucose)
RN  - 0 (Chalcones)
RN  - 0 (Hypoglycemic Agents)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - JTV5467968 (licochalcone A)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Chalcones
MH  - *Diabetes Mellitus, Experimental/drug therapy
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Hypoglycemic Agents/pharmacology
MH  - *Insulin Resistance
MH  - Mice
MH  - Phosphatidylinositol 3-Kinases/genetics
MH  - Proto-Oncogene Proteins c-akt/genetics
MH  - Streptozocin
OTO - NOTNLM
OT  - hypoglycemic
OT  - hypolipidemic
OT  - licochalcone A
OT  - mechanism
OT  - type 2 diabetes mellitus
EDAT- 2021/02/20 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/02/19 08:38
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/02/19 08:38 [entrez]
AID - 10.1021/acs.jafc.0c07630 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2021 Mar 3;69(8):2444-2456. doi: 10.1021/acs.jafc.0c07630. 
      Epub 2021 Feb 19.