PMID- 33605307
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20231110
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Print)
IS  - 0102-8650 (Linking)
VI  - 36
IP  - 1
DP  - 2021
TI  - Study on the effect of the treatment of Periplaneta americana L. extract Ento-B 
      by Dinitrochlorobenzene combined with acetic acid induced UC in rats.
PG  - e360102
LID - S0102-86502021000100204 [pii]
LID - 10.1590/ACB360102 [doi]
LID - e360102
AB  - PURPOSE: To study the Periplaneta americana L. extract Ento-B on the treatment of 
      chronic ulcerative colitis induced by 2,4-dinitrochlorobenzene and acetic acid in 
      rats and to explore its primary mechanism of action. METHODS: Using 
      2,4-dinitrochlorobenzene combined with acetic acid to induce chronic ulcerative 
      colitis (chronic UC) in rats. The sulfasalazine (400 mg/kg) and Ento-B (200 
      mg/kg, 100 mg/kg,50 mg/kg) were given by intragastric administration and the 
      effect was evaluated according to the disease activity index (DAI) score, colon 
      mucosal injury index (CMDI) score, histopathological score (HS) and the serum 
      levels of Interleukin-4(IL-4), Interleukin-10(IL-10), Tumor necrosis 
      factor-alpha(TNF-alpha), Malondialdehyde(MDA), Superoxide dismutase(SOD) and Inducible 
      nitric oxide synthase(iNOS.). RESULTS: Compared with the model group, all doses 
      of Ento-B could reduce the score of CMDI (p < 0.05), HS(p < 0.05 or p < 0.01), 
      significantly increased the expression of IL-4, IL-10, SOD (p < 0.01) and 
      decreased the levels of TNF-alpha, MDA, iNOS in serum of UC rats, significantly 
      improving the degree of colon lesionsin UC rats. CONCLUSIONS: Ento-B may play an 
      important role in the treatment of ulcerative colitis induced byUC rats. The 
      mechanism may be related to the increased expression of IL-4, IL-10, SOD and 
      reduced expression of TNF-alpha, MDA, iNOS.
FAU - Liu, Sheng-Shuai
AU  - Liu SS
AUID- ORCID: 0000-0003-3307-0163
AD  - MM. Dali University - Yunnan Provincial Key Laboratory of Entomological 
      Biopharmaceutical R&D - Yunnan, China.
FAU - Xu, Yu-Sheng
AU  - Xu YS
AUID- ORCID: 0000-0001-5271-1080
AD  - MD. Hunan Agricultural University - Changsha, Hunan, China.
FAU - Hilola, Ahunova
AU  - Hilola A
AUID- ORCID: 0000-0002-4089-9431
AD  - MD. Namangan State University - Life Sciences Faculty - Uzbekistan, China.
FAU - Zhou, Nong
AU  - Zhou N
AUID- ORCID: 0000-0003-1236-8585
AD  - MD. Chongqing Three Gorges University - College of Biology and Food Engineering - 
      Chongqing Engineering Laboratory - Chongqing, China.
FAU - He, Miao
AU  - He M
AUID- ORCID: 0000-0002-1887-1512
AD  - MD. Dali University - National-Local Joint Engineering Research Center of 
      Entomoceutics - Yunnan, China.
FAU - Zhang, Cheng-Gui
AU  - Zhang CG
AUID- ORCID: 0000-0002-2691-5079
AD  - MD. Dali University - National-Local Joint Engineering Research Center of 
      Entomoceutics - Yunnan, China.
FAU - Liu, Heng
AU  - Liu H
AUID- ORCID: 0000-0003-3937-4985
AD  - MD. Dali University - Yunnan Provincial Key Laboratory of Entomological 
      Biopharmaceutical R&D - Yunnan, China.
LA  - eng
PT  - Journal Article
DEP - 20210215
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - Q40Q9N063P (Acetic Acid)
SB  - IM
MH  - Acetic Acid
MH  - Animals
MH  - *Colitis, Ulcerative/chemically induced/drug therapy
MH  - Colon
MH  - Dinitrochlorobenzene
MH  - *Periplaneta
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Rats
MH  - Tumor Necrosis Factor-alpha
PMC - PMC7892194
COIS- Conflict of interest: Nothing to declare.
EDAT- 2021/02/20 06:00
MHDA- 2021/02/23 06:00
PMCR- 2021/02/15
CRDT- 2021/02/19 08:39
PHST- 2020/09/03 00:00 [received]
PHST- 2020/12/02 00:00 [accepted]
PHST- 2021/02/19 08:39 [entrez]
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2021/02/15 00:00 [pmc-release]
AID - S0102-86502021000100204 [pii]
AID - 10.1590/ACB360102 [doi]
PST - epublish
SO  - Acta Cir Bras. 2021 Feb 15;36(1):e360102. doi: 10.1590/ACB360102. eCollection 
      2021.