PMID- 33606443 OWN - NLM STAT- MEDLINE DCOM- 20211029 LR - 20211029 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 32 IP - 7 DP - 2021 Oct 1 TI - Real Appearance of Dendritic Cell on Failed Implant Fixture. PG - e607-e609 LID - 10.1097/SCS.0000000000007563 [doi] AB - Dendritic cells (DCs) are considered a multifunctional cell population that links the innate and adaptive immune systems. Dendritic cells have a capacity for antigen capture and presentation to T cells, which initiates a cascade of inflammatory reactions. On contrary to its importance in immunology, DCs have not been known well in peri-implantitis.A scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy examination was used to examine a fixture that failed due to peri-implantitis, and a transmission electron microscopy was used to examine the peri-implant inflamed soft tissue. The presence of a DC was suggested in both scanning electron microscopy and transmission electron microscopy images. Titanium elements were also detected in the fixture-attached bone with energy-dispersive X-ray spectroscopy analysis. These findings suggested a link between Ti particles and DCs activation. The correlation between the presence of Ti particles and DCs will help to elucidate the detailed mechanism of peri-implantitis. CI - Copyright (c) 2021 by Mutaz B. Habal, MD. FAU - Nguyen, Truc Thi Hoang AU - Nguyen TTH AD - Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea. FAU - Eo, Mi Young AU - Eo MY FAU - Kim, Soung Min AU - Kim SM LA - eng PT - Journal Article PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 RN - 0 (Dental Implants) RN - D1JT611TNE (Titanium) MH - Dendritic Cells MH - *Dental Implants MH - Humans MH - Microscopy, Electron, Scanning MH - *Peri-Implantitis MH - Spectrometry, X-Ray Emission MH - Titanium COIS- The authors report no conflicts of interest. EDAT- 2021/02/20 06:00 MHDA- 2021/10/30 06:00 CRDT- 2021/02/19 12:42 PHST- 2021/02/20 06:00 [pubmed] PHST- 2021/10/30 06:00 [medline] PHST- 2021/02/19 12:42 [entrez] AID - 00001665-900000000-92817 [pii] AID - 10.1097/SCS.0000000000007563 [doi] PST - ppublish SO - J Craniofac Surg. 2021 Oct 1;32(7):e607-e609. doi: 10.1097/SCS.0000000000007563.