PMID- 33606994
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20211117
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Linking)
VI  - 39
IP  - 5
DP  - 2021 May 10
TI  - The human leukocyte antigen as a candidate tumor suppressor.
PG  - 586-589
LID - S1535-6108(21)00107-0 [pii]
LID - 10.1016/j.ccell.2021.02.005 [doi]
AB  - Here we argue in support of the human leukocyte antigen (HLA) supergene as a 
      tumor suppressor. HLA is a recurring mutational target in a large and diverse 
      group of malignancies. The tumor suppressor function of HLA is linked to an 
      embryonic/stemness and drug resistance phenotype. A deeper understanding of the 
      distinct roles of HLA, including immunosurveillance, stemness, and tumor 
      suppressor functions, could illuminate the limited responses in cancer patients. 
      Furthermore, it would provide guidelines for the design of new therapeutic 
      strategies, including the potential of modulating HLA expression in the tumor 
      stem cell compartment.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Pujadas, Elisabet
AU  - Pujadas E
AD  - Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of 
      Medicine at Mount Sinai, New York, NY, USA.
FAU - Cordon-Cardo, Carlos
AU  - Cordon-Cardo C
AD  - Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of 
      Medicine at Mount Sinai, New York, NY, USA. Electronic address: 
      carlos.cordon-cardo@mssm.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210218
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Genes, Tumor Suppressor/*drug effects
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens/*therapeutic use
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Monitoring, Immunologic/methods
MH  - Neoplasms/immunology/*therapy
EDAT- 2021/02/20 06:00
MHDA- 2021/11/18 06:00
CRDT- 2021/02/19 20:10
PHST- 2021/02/20 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/02/19 20:10 [entrez]
AID - S1535-6108(21)00107-0 [pii]
AID - 10.1016/j.ccell.2021.02.005 [doi]
PST - ppublish
SO  - Cancer Cell. 2021 May 10;39(5):586-589. doi: 10.1016/j.ccell.2021.02.005. Epub 
      2021 Feb 18.