PMID- 33607776
OWN - NLM
STAT- MEDLINE
DCOM- 20210303
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 7
DP  - 2021 Feb 19
TI  - Clinical features and prognostic factors of critically ill patients with COVID-19 
      in Daegu, South Korea: A multi-center retrospective study.
PG  - e24437
LID - 10.1097/MD.0000000000024437 [doi]
LID - e24437
AB  - To describe the clinical and demographic characteristics of critically ill 
      patients with COVID-19 in Daegu, South Korea, and to explore the risk factors for 
      in-hospital mortality in these patients.Retrospective cohort study of 110 
      critically ill patients with COVID-19 admitted to the ICU in Daegu, South Korea, 
      between February 18 and April 5, 2020. The final date of follow-up was April 20, 
      2020.A total of 110 patient medical records were reviewed. The median age was 
      71 years (interquartile range [IQR] = 63-78 years). During the study period, 47 
      patients (42.7%) died in the hospital. The most common SARS-CoV-2 infection 
      related complication was acute respiratory distress syndrome (ARDS) in 95 
      patients (86.4%). Of the 79 patients (71.8%) who received invasive mechanical 
      ventilation, 46 (58.2%) received neuromuscular blockade injection, and 19 (24.1%) 
      received ECMO treatment. All patients received antibiotic injection, 99 patients 
      (90%) received hydroxychloroquine, 96 patients (87.3%) received 
      lopinavir-ritonavir antiviral medication, and 14 patients (12.7%) received other 
      antiviral agents, including darunavir-cobicistat and emtricitabine-tenofovir. In 
      the multivariable logistic regression model, the odds ratio of in-hospital death 
      was higher with APACHE II score (OR = 1.126; 95% CI = 1.014-1.252; P  = .027).The 
      in-hospital mortality rate of critically ill patients with COVID-19 was 
      approximately 40%. Higher APACHE II score at admission was an independent risk 
      factor for death in these patients.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Kim, Eun Jin
AU  - Kim EJ
AD  - Division of Pulmonary and Critical Care Medicine, Daegu Catholic university 
      hospital.
FAU - Lee, Yong Hoon
AU  - Lee YH
AD  - Department of Internal Medicine, School of Medicine, Kyungpook National 
      University.
FAU - Park, Jae Seok
AU  - Park JS
AD  - Division of Pulmonology, Department of Internal Medicine, Keimyung University 
      Dongsan Hospital, Keimyung University School of Medicine.
FAU - Lee, Jaehee
AU  - Lee J
AD  - Department of Internal Medicine, School of Medicine, Kyungpook National 
      University.
FAU - Lee, Shin Yup
AU  - Lee SY
AD  - Division of Pulmonary and Critical Care Medicine, Kyungpook National University 
      Chilgok Hospital.
FAU - Kim, Yeonjae
AU  - Kim Y
AD  - Division of Pulmonary and Critical Care Medicine, Deagu Fatima Hospital.
FAU - Kwon, Yong Shik
AU  - Kwon YS
AD  - Division of Pulmonology, Department of Internal Medicine, Keimyung University 
      Dongsan Hospital, Keimyung University School of Medicine.
FAU - Jang, Jong Geol
AU  - Jang JG
AD  - Division of Pulmonary and Critical Care Medicine, Yeungnam University Medical 
      Center, Daegu, Republic of Korea.
FAU - Shin, Kyeong-Cheol
AU  - Shin KC
AD  - Division of Pulmonary and Critical Care Medicine, Yeungnam University Medical 
      Center, Daegu, Republic of Korea.
FAU - Kim, Kyung Chan
AU  - Kim KC
AD  - Division of Pulmonary and Critical Care Medicine, Daegu Catholic university 
      hospital.
FAU - Choi, Eun Young
AU  - Choi EY
AD  - Division of Pulmonary and Critical Care Medicine, Yeungnam University Medical 
      Center, Daegu, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Drosophila Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (ex protein, Drosophila)
SB  - IM
MH  - APACHE
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - COVID-19/*mortality/*therapy
MH  - Comorbidity
MH  - Critical Illness/*mortality/*therapy
MH  - Drosophila Proteins
MH  - Extracorporeal Membrane Oxygenation/statistics & numerical data
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Membrane Proteins
MH  - Middle Aged
MH  - Prognosis
MH  - Republic of Korea/epidemiology
MH  - Respiration, Artificial/methods/statistics & numerical data
MH  - Retrospective Studies
MH  - Risk Factors
MH  - SARS-CoV-2
PMC - PMC7899898
COIS- The authors declare no competing interests.
EDAT- 2021/02/21 06:00
MHDA- 2021/03/04 06:00
PMCR- 2021/02/19
CRDT- 2021/02/20 01:01
PHST- 2020/05/04 00:00 [received]
PHST- 2021/01/05 00:00 [accepted]
PHST- 2021/02/20 01:01 [entrez]
PHST- 2021/02/21 06:00 [pubmed]
PHST- 2021/03/04 06:00 [medline]
PHST- 2021/02/19 00:00 [pmc-release]
AID - 00005792-202102190-00015 [pii]
AID - MD-D-20-04017 [pii]
AID - 10.1097/MD.0000000000024437 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Feb 19;100(7):e24437. doi: 
      10.1097/MD.0000000000024437.