PMID- 3360803
OWN - NLM
STAT- MEDLINE
DCOM- 19880609
LR  - 20210210
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 263
IP  - 14
DP  - 1988 May 15
TI  - The complete primary structure of human matrix metalloproteinase-3. Identity with 
      stromelysin.
PG  - 6742-5
AB  - We have determined the complete primary structure for human matrix 
      metalloproteinase-3 (MMP-3), which has 477 residues including a 17-residue signal 
      peptide. The result indicates that MMP-3 is identical with stromelysin (Whitham, 
      S. E., Murphy, G., Angel, P., Rahmsdorf, H.-J., Smith, B. J., Lyons, A., Harris, 
      T. J. R., Reynolds, J. J., Herrlich, P., and Docherty, A. J. P. (1986) Biochem. 
      J. 240, 913-916). A striking result is that MMP-3 and collagenase are 54% 
      identical in sequence, suggesting a common origin for the evolution of the two 
      proteinases. We also show that in human synovial fibroblast cultures human 
      recombinant interleukin-1 beta rapidly induces high levels of MMP-3 mRNA and, 
      conversely, that retinoic acid or dexamethasone can suppress the MMP-3 mRNA 
      levels. Similar results were obtained for human synovial collagenase mRNA. The 
      data suggest that MMP-3 and collagenase expression are coordinately modulated in 
      synovial fibroblast cultures.
FAU - Saus, J
AU  - Saus J
AD  - Department of Medicine, University of Medicine and Dentistry of New Jersey, 
      Robert Wood Johnson Medical School, Piscataway 08854.
FAU - Quinones, S
AU  - Quinones S
FAU - Otani, Y
AU  - Otani Y
FAU - Nagase, H
AU  - Nagase H
FAU - Harris, E D Jr
AU  - Harris ED Jr
FAU - Kurkinen, M
AU  - Kurkinen M
LA  - eng
SI  - GENBANK/J03209
GR  - AR 33714/AR/NIAMS NIH HHS/United States
GR  - GM 34090/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Arthritis, Rheumatoid/enzymology
MH  - Base Sequence
MH  - Cells, Cultured
MH  - Humans
MH  - Matrix Metalloproteinase 3
MH  - Metalloendopeptidases/*genetics/isolation & purification
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics
MH  - Rabbits
MH  - Sequence Homology, Nucleic Acid
MH  - Synovial Membrane/*enzymology
EDAT- 1988/05/15 00:00
MHDA- 2001/03/28 10:01
CRDT- 1988/05/15 00:00
PHST- 1988/05/15 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1988/05/15 00:00 [entrez]
AID - S0021-9258(18)68705-8 [pii]
PST - ppublish
SO  - J Biol Chem. 1988 May 15;263(14):6742-5.