PMID- 33609316
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20230102
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1507
IP  - 1
DP  - 2022 Jan
TI  - Enhancing cardiac arrest survival with extracorporeal cardiopulmonary 
      resuscitation: insights into the process of death.
PG  - 37-48
LID - 10.1111/nyas.14580 [doi]
AB  - Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging method of 
      cardiopulmonary resuscitation to improve outcomes from cardiac arrest. This 
      approach targets patients with out-of-hospital cardiac arrest previously 
      unresponsive and refractory to standard treatment, combining approximately 1 h of 
      standard CPR followed by venoarterial extracorporeal membrane oxygenation 
      (VA-ECMO) and coronary artery revascularization. Despite its relatively new 
      emergence for the treatment of cardiac arrest, the approach is grounded in a vast 
      body of preclinical and clinical data that demonstrate significantly improved 
      survival and neurological outcomes despite unprecedented, prolonged periods of 
      CPR. In this review, we detail the principles behind VA-ECMO-facilitated 
      resuscitation, contemporary clinical approaches with outcomes, and address the 
      emerging new understanding of the process of death and capability for 
      neurological recovery.
CI  - (c) 2021 New York Academy of Sciences.
FAU - Aufderheide, Tom P
AU  - Aufderheide TP
AD  - Department of Emergency Medicine, HUB for Collaborative Medicine, Medical College 
      of Wisconsin, Milwaukee, Wisconsin.
FAU - Kalra, Rajat
AU  - Kalra R
AD  - Center for Resuscitation Medicine, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
AD  - Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota.
FAU - Kosmopoulos, Marinos
AU  - Kosmopoulos M
AD  - Center for Resuscitation Medicine, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
FAU - Bartos, Jason A
AU  - Bartos JA
AD  - Center for Resuscitation Medicine, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
AD  - Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota.
FAU - Yannopoulos, Demetris
AU  - Yannopoulos D
AD  - Center for Resuscitation Medicine, University of Minnesota Medical School, 
      Minneapolis, Minnesota.
AD  - Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota.
LA  - eng
GR  - R33 HL142696/HL/NHLBI NIH HHS/United States
GR  - R61 HL142696/HL/NHLBI NIH HHS/United States
GR  - Leona M. and Harry B. Helmsley Charitable Trust/
GR  - 4R33HL142696-02/HL/NHLBI NIH HHS/United States
GR  - 4R33HL142696-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210220
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Brain/physiopathology
MH  - Cardiopulmonary Resuscitation/*methods/*mortality
MH  - Death
MH  - Extracorporeal Membrane Oxygenation/*methods/*mortality
MH  - Humans
MH  - Nervous System Diseases/mortality/physiopathology/therapy
MH  - Out-of-Hospital Cardiac Arrest/*mortality/physiopathology/*therapy
MH  - Survival/physiology
PMC - PMC8377067
MID - NIHMS1673974
OTO - NOTNLM
OT  - brain death
OT  - cardiopulmonary resuscitation
OT  - extracorporeal cardiopulmonary resuscitation
OT  - extracorporeal membrane oxygenation
OT  - neurological prognostication
OT  - neurological recovery
COIS- Competing interests The authors declare no competing interests.
EDAT- 2021/02/21 06:00
MHDA- 2022/02/09 06:00
PMCR- 2023/01/01
CRDT- 2021/02/20 12:07
PHST- 2021/01/30 00:00 [revised]
PHST- 2020/10/28 00:00 [received]
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/02/21 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2021/02/20 12:07 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.1111/nyas.14580 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2022 Jan;1507(1):37-48. doi: 10.1111/nyas.14580. Epub 2021 Feb 
      20.