PMID- 33611105
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 151
DP  - 2021 Jun
TI  - Wood emissions and asthma development: Results from an experimental mouse model 
      and a prospective cohort study.
PG  - 106449
LID - S0160-4120(21)00074-X [pii]
LID - 10.1016/j.envint.2021.106449 [doi]
AB  - BACKGROUND: Increased use of renewable resources like sustainably produced wood 
      in construction or for all sorts of long-lived products is considered to 
      contribute to reducing society's carbon footprint. However, as a natural, 
      biological material, wood and wood products emit specific volatile organic 
      compounds (VOCs). Therefore, the evaluation of possible health effects due to 
      wood emissions is of major interest. OBJECTIVES: We investigated the effects of 
      an exposure to multiple wood-related VOCs on asthma development. METHODS: A 
      murine asthma model was used to evaluate possible allergic and inflammatory 
      effects on the lung after short- or long-term and perinatal exposure to pinewood 
      or oriented strand board (OSB). In addition, wood-related VOCs were measured 
      within the German prospective mother-child cohort LINA and their joint effect on 
      early wheezing or asthma development in children until the age of 10 was 
      estimated by Bayesian kernel machine regression (BKMR) stratifying also for 
      family history of atopy (FHA). RESULTS: Our experimental data show that neither 
      pinewood nor OSB emissions even at high total VOC levels and a long-lasting 
      exposure period induce significant inflammatory or asthma-promoting effects in 
      sensitized or non-sensitized mice. Moreover, an exposure during the vulnerable 
      time window around birth was also without effect. Consistently, in our 
      mother-child cohort LINA, an exposure to multiple wood-related VOCs during 
      pregnancy or the first year of life was not associated with early wheezing or 
      asthma development in children independent from their FHA. CONCLUSION: Our 
      findings indicate that emissions from wood and wood products at levels commonly 
      occurring in the living environment do not exert adverse effects concerning 
      wheezing or asthma development.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Junge, Kristin M
AU  - Junge KM
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Environmental Immunology, Leipzig, Germany.
FAU - Buchenauer, Lisa
AU  - Buchenauer L
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology 
      and Allergology, Leipzig University Medical Center, University of Leipzig, 
      Leipzig, Germany.
FAU - Elter, Elena
AU  - Elter E
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology 
      and Allergology, Leipzig University Medical Center, University of Leipzig, 
      Leipzig, Germany.
FAU - Butter, Katja
AU  - Butter K
AD  - Thunen Institute of Wood Research, Hamburg, Germany.
FAU - Kohajda, Tibor
AU  - Kohajda T
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Molecular Systems Biology, Leipzig, Germany.
FAU - Herberth, Gunda
AU  - Herberth G
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Environmental Immunology, Leipzig, Germany.
FAU - Roder, Stefan
AU  - Roder S
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Environmental Immunology, Leipzig, Germany.
FAU - Borte, Michael
AU  - Borte M
AD  - Children's Hospital, Municipal Hospital "St. Georg", Leipzig, Germany.
FAU - Kiess, Wieland
AU  - Kiess W
AD  - University of Leipzig, Hospital for Children and Adolescents - Centre for 
      Pediatric Research, Leipzig, Germany; University of Leipzig, LIFE - Leipzig 
      Research Centre for Civilization Diseases, Leipzig, Germany.
FAU - von Bergen, Martin
AU  - von Bergen M
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Molecular Systems Biology, Leipzig, Germany; University of Leipzig, Faculty of 
      Life Sciences, Institute of Biochemistry, Leipzig, Germany.
FAU - Simon, Jan C
AU  - Simon JC
AD  - Department of Dermatology, Venerology and Allergology, Leipzig University Medical 
      Center, University of Leipzig, Leipzig, Germany.
FAU - Rolle-Kampczyk, Ulrike E
AU  - Rolle-Kampczyk UE
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Molecular Systems Biology, Leipzig, Germany.
FAU - Lehmann, Irina
AU  - Lehmann I
AD  - Charite - Universitatsmedizin Berlin, Environmental Epigenetics and Lung Research 
      Group, Berlin, Germany; Berlin Institute of Health (BIH), Molecular Epidemiology, 
      Berlin, Germany.
FAU - Gminski, Richard
AU  - Gminski R
AD  - Institute for Infection Prevention and Hospital Epidemiology, Environmental 
      Medicine, Faculty of Medicine and Medical Center, University of Freiburg, 
      Freiburg, Germany.
FAU - Ohlmeyer, Martin
AU  - Ohlmeyer M
AD  - Thunen Institute of Wood Research, Hamburg, Germany.
FAU - Polte, Tobias
AU  - Polte T
AD  - UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of 
      Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology 
      and Allergology, Leipzig University Medical Center, University of Leipzig, 
      Leipzig, Germany. Electronic address: tobias.polte@ufz.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210218
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Animals
MH  - *Asthma/chemically induced
MH  - Bayes Theorem
MH  - Mice
MH  - Prospective Studies
MH  - *Volatile Organic Compounds/toxicity
MH  - Wood
OTO - NOTNLM
OT  - Asthma
OT  - FHA
OT  - LINA cohort
OT  - Mixture effect
OT  - Murine asthma model
OT  - Perinatal exposure
OT  - Volatile organic compounds
OT  - Wheezing
OT  - Wood emission
EDAT- 2021/02/22 06:00
MHDA- 2021/04/27 06:00
CRDT- 2021/02/21 20:36
PHST- 2020/10/02 00:00 [received]
PHST- 2020/12/22 00:00 [revised]
PHST- 2021/02/03 00:00 [accepted]
PHST- 2021/02/22 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2021/02/21 20:36 [entrez]
AID - S0160-4120(21)00074-X [pii]
AID - 10.1016/j.envint.2021.106449 [doi]
PST - ppublish
SO  - Environ Int. 2021 Jun;151:106449. doi: 10.1016/j.envint.2021.106449. Epub 2021 
      Feb 18.