PMID- 33611106 OWN - NLM STAT- MEDLINE DCOM- 20210426 LR - 20210426 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 151 DP - 2021 Jun TI - Sustained bloodstream release of persistent organic pollutants induced by extensive weight loss after bariatric surgery: Implications for women of childbearing age. PG - 106400 LID - S0160-4120(21)00024-6 [pii] LID - 10.1016/j.envint.2021.106400 [doi] AB - BACKGROUND: Lipophilic persistent organic pollutants (POPs) are stored in adipose tissues and released in case of weight loss. OBJECTIVES: To analyze the kinetics and characteristics of this release during drastic weight loss after bariatric surgery and compare the results in case of women of childbearing age (WCBA) with critical blood concentration thresholds. METHODS: 100 morbidly obese patients (73 women including 53 of childbearing age and 27 men) were screened before and 3, 6 and 12 months after bariatric surgery for serum concentrations of 67 congeners or metabolites of banned or not yet banned organohalogenated persistent pollutants, including highly lipophilic polychlorobiphenyls (PCBs), organochlorine pesticides (OCPs), brominated flame retardants (BFRs), and less lipophilic perfluorinated alkylated substances (PFASs). RESULTS: Circulating levels of all chemicals, except PFASs, increased progressively after surgery, reaching after one year an increase between 30 and 139% compared to initial pre-surgical levels; median levels increased for PCB153 from 36.8 to 86.4 ng/g lw (+130%), for dichlorodiphenyldichloroethylene (p,p'-DDE) from 59.8 to 136.1 ng/g lw (+120%), and for hexachlorobenzene (HCB) from 9.8 to 20.3 ng/g lw (+110%). Weight loss averaging 30% of initial body weight at 12 months in both sexes (mean: 40.0 kg for men, 36.1 kg for women), was the main parameter related to the concentration increases (3.1 to 3.6% per kilogram weight loss). They were not dependent on initial BMI, presence of metabolic syndrome or type of surgical procedure but influenced by gender and biochemical properties such as degree of chlorination for PCBs and/or lipophilicity since PFASs did not increase at all. summation operatorPCB(6) in blood after one year exceeded the critical concentration threshold for 24.5% women of childbearing age (13/53) versus 3.6% (2/53) before surgery. DISCUSSION: Massive weight loss within the first year following bariatric surgery is associated with a sustained increase of circulating lipophilic POPs. Short- and long-term consequences should be considered, mostly for childbearing age obese women, because of potential health risks for the future fetus and breastfeeding infant. CI - Copyright (c) 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Fenichel, Patrick AU - Fenichel P AD - Universite Cote d'Azur, University Hospital of Nice, Department of Endocrinology, Diabetology and Reproduction, Nice, France; Universite Cote d'Azur, INSERM U1065, C3M, Nice, France. Electronic address: Fenichel.p@chu-nice.fr. FAU - Coquillard, Patrick AU - Coquillard P AD - Laboratory I3S, Sophia Antipolis, Universite Cote d'Azur, Nice, France. Electronic address: Patrick.coquillard@unice.fr. FAU - Brucker-Davis, Francoise AU - Brucker-Davis F AD - Universite Cote d'Azur, University Hospital of Nice, Department of Endocrinology, Diabetology and Reproduction, Nice, France. Electronic address: jmichaeldavis@wanadoo.fr. FAU - Marchand, Philippe AU - Marchand P AD - LABERCA, Oniris, INRAE, 44307 Nantes, France. Electronic address: Philippe.marchand@oniris-nantes.fr. FAU - Cano-Sancho, German AU - Cano-Sancho G AD - LABERCA, Oniris, INRAE, 44307 Nantes, France. Electronic address: German.Cano-Sancho@oniris-nantes.fr. FAU - Boda, Mireille AU - Boda M AD - Universite Cote d'Azur, University Hospital of Nice, Department of Endocrinology, Diabetology and Reproduction, Nice, France. Electronic address: Boda.m@chu-nice.fr. FAU - Antignac, Jean-Philippe AU - Antignac JP AD - LABERCA, Oniris, INRAE, 44307 Nantes, France. Electronic address: Jean-philippe.antignac@oniris-nantes.fr. FAU - Iannelli, Antonio AU - Iannelli A AD - Department of DigestiveSurgery, Archet II Hospital, Universite Cote d'Azur, Nice, France. Electronic address: Iannelli.a@chu-nice.fr. FAU - Gugenheim, Jean AU - Gugenheim J AD - Department of DigestiveSurgery, Archet II Hospital, Universite Cote d'Azur, Nice, France. Electronic address: Gugenheim.j@chu-nice.fr. FAU - Le Bizec, Bruno AU - Le Bizec B AD - LABERCA, Oniris, INRAE, 44307 Nantes, France. Electronic address: Bruno.lebizec@oniris-nantes.fr. FAU - Chevalier, Nicolas AU - Chevalier N AD - Universite Cote d'Azur, University Hospital of Nice, Department of Endocrinology, Diabetology and Reproduction, Nice, France; Universite Cote d'Azur, INSERM U1065, C3M, Nice, France. Electronic address: Chevalier.n@chu-nice.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210218 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Pesticides) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adult MH - *Bariatric Surgery MH - *Environmental Pollutants/analysis MH - Female MH - Humans MH - *Hydrocarbons, Chlorinated/analysis MH - Male MH - *Obesity, Morbid/surgery MH - Persistent Organic Pollutants MH - *Pesticides/analysis MH - *Polychlorinated Biphenyls/analysis MH - Weight Loss OTO - NOTNLM OT - Bariatric surgery OT - Critical exposure values OT - Endocrine disruptors OT - Morbid obesity OT - Persistent organic pollutants OT - Women of childbearing age EDAT- 2021/02/22 06:00 MHDA- 2021/04/27 06:00 CRDT- 2021/02/21 20:36 PHST- 2020/10/03 00:00 [received] PHST- 2021/01/11 00:00 [revised] PHST- 2021/01/12 00:00 [accepted] PHST- 2021/02/22 06:00 [pubmed] PHST- 2021/04/27 06:00 [medline] PHST- 2021/02/21 20:36 [entrez] AID - S0160-4120(21)00024-6 [pii] AID - 10.1016/j.envint.2021.106400 [doi] PST - ppublish SO - Environ Int. 2021 Jun;151:106400. doi: 10.1016/j.envint.2021.106400. Epub 2021 Feb 18.