PMID- 33612021
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230719
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 129
IP  - 4
DP  - 2023 Dec
TI  - Intergenic lnc-LEP-2:6 and lnc-LEP-2:7 as novel biomarkers associated with type 2 
      diabetes mellitus.
PG  - 958-963
LID - 10.1080/13813455.2021.1887268 [doi]
AB  - CONTEXT: Type 2 diabetes mellitus (T2DM) has undeniably become a significant 
      threat to public health in the modern world. OBJECTIVE: To identify molecules 
      involved in the development of T2DM, the expression patterns of cis-lincRNAs-LEP 
      were investigated in T2DM patients. MATERIALS AND METHODS: The expression levels 
      of 11 lncRNAs-LEP and LEP mRNA in 71 diabetic patients and 32 controls were 
      determined using qRT-PCR. The association between lncRNAs-LEP and T2DM was 
      performed using ROC curve analysis. RESULTS: The expression analysis of 
      lnc-LEP-2:6 and lnc-LEP-2:7 was significantly different (p</= .0001) in diabetic 
      patients compared to the controls. The ROC curve data showed that lnc-LEP-2:6 and 
      lnc-LEP-2:7 have a high AUC, with 0.940 (95% CI: 0.875-0.977) and 0.958 (95% CI: 
      0.899-0.988), respectively. CONCLUSIONS: Our results revealed two novel 
      biomarkers associated with the T2DM and suggest that the circulating intergenic, 
      lnc-LEP-2:6 and lnc-LEP-2:7, might have a regulatory role in the disease 
      pathogenesis.
FAU - Alomari, Amani S
AU  - Alomari AS
AD  - Department of Biochemistry, King AbdulAziz University, Jeddah, Saudi Arabia.
FAU - Al-Harithy, Rowyda N
AU  - Al-Harithy RN
AD  - Department of Biochemistry, King AbdulAziz University, Jeddah, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20210221
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - *RNA, Long Noncoding/genetics
MH  - Biomarkers
MH  - Polymerase Chain Reaction
MH  - ROC Curve
OTO - NOTNLM
OT  - Leptin gene
OT  - T2DM
OT  - lnc-LEP-2:6
OT  - lnc-LEP-2:7
OT  - lncRNAs
EDAT- 2021/02/23 06:00
MHDA- 2023/07/19 06:42
CRDT- 2021/02/22 05:43
PHST- 2023/07/19 06:42 [medline]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/02/22 05:43 [entrez]
AID - 10.1080/13813455.2021.1887268 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2023 Dec;129(4):958-963. doi: 
      10.1080/13813455.2021.1887268. Epub 2021 Feb 21.