PMID- 33612591
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 66
IP  - Supplement
DP  - 2020
TI  - Effects of High and Low Sugar Diets on Cardiovascular Disease Risk Factors.
PG  - S18-S24
LID - 10.3177/jnsv.66.S18 [doi]
AB  - It has been proposed that a high sugar intake was associated with cardiovascular 
      disease (CVD) risk and metabolic syndrome depending on the amount of carbohydrate 
      (CHO), other nutrients in foods, and underlying metabolic disturbances. This 
      study aimed to investigate the effects of high (HS) and low sugar (LS) diets on 
      metabolic profiles in 25 middle-aged men at increased CVD risk in a 12-week 
      randomised cross-over intervention study. An isocaloric dietary exchanged model 
      consisted of HS (24% energy from sugar) and LS (6% energy from sugar) with 
      comparable total CHO, fat and fibre composition in normal foods was used. 
      Anthropometric, blood pressure and plasma lipid profile were measured pre- and 
      post-intervention. Body weight, waist circumference and fat mass increased and 
      decreased significantly after HS (by 0.7+/-0.3 kg, 1.4+/-1.0 cm and 0.5+/-0.3 kg) and 
      LS (by 2.1+/-0.5 kg, 2.0+/-0.8 cm and 1.4+/-0.3 kg) (p<0.05), respectively. Plasma TG 
      increased significantly after HS by 0.26+/-0.07 mmol/L and decreased after LS by 
      0.35+/-0.16 mmol/L. Plasma HDL decreased by 0.11+/-0.03 mmol/L (p<0.05) after HS, 
      whilst, plasma TC and LDL decreased significantly by 10% after LS. There was no 
      significant change in other parameters after either diet. This study confirmed 
      that a diet with a greater proportion of sugar increased CVD risk via negative 
      changes in metabolic profiles including body weight, waist circumference and 
      lipid parameters, whereas LS produced the positive effects. A restriction of 
      sugar intake to lower than 10% energy intake is vital to reduce CVD risk.
FAU - Ahmad, Aryati
AU  - Ahmad A
AD  - Faculty of Health Sciences, Universiti Sultan Zainal Abidin.
AD  - Faculty of Health & Medical Sciences, University of Surrey.
FAU - Isherwood, Cheryl
AU  - Isherwood C
AD  - Faculty of Health & Medical Sciences, University of Surrey.
FAU - Umpleby, Margot
AU  - Umpleby M
AD  - Faculty of Health & Medical Sciences, University of Surrey.
FAU - Griffin, Bruce
AU  - Griffin B
AD  - Faculty of Health & Medical Sciences, University of Surrey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Sugars)
SB  - IM
MH  - *Cardiovascular Diseases/etiology/prevention & control
MH  - Diet, Carbohydrate-Restricted
MH  - Energy Intake
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sugars
OTO - NOTNLM
OT  - cardiovascular disease
OT  - high sugar
OT  - low sugar
OT  - risk factors
EDAT- 2021/02/23 06:00
MHDA- 2021/09/01 06:00
CRDT- 2021/02/22 05:50
PHST- 2021/02/22 05:50 [entrez]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
AID - 10.3177/jnsv.66.S18 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2020;66(Supplement):S18-S24. doi: 
      10.3177/jnsv.66.S18.