PMID- 33613188
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Selenium at the Neural Barriers: A Review.
PG  - 630016
LID - 10.3389/fnins.2021.630016 [doi]
LID - 630016
AB  - Selenium (Se) is known to contribute to several vital physiological functions in 
      mammals: antioxidant defense, fertility, thyroid hormone metabolism, and immune 
      response. Growing evidence indicates the crucial role of Se and Se-containing 
      selenoproteins in the brain and brain function. As for the other essential trace 
      elements, dietary Se needs to reach effective concentrations in the central 
      nervous system (CNS) to exert its functions. To do so, Se-species have to cross 
      the blood-brain barrier (BBB) and/or blood-cerebrospinal fluid barrier (BCB) of 
      the choroid plexus. The main interface between the general circulation of the 
      body and the CNS is the BBB. Endothelial cells of brain capillaries forming the 
      so-called tight junctions are the primary anatomic units of the BBB, mainly 
      responsible for barrier function. The current review focuses on Se transport to 
      the brain, primarily including selenoprotein P/low-density lipoprotein 
      receptor-related protein 8 (LRP8, also known as apolipoprotein E receptor-2) 
      dependent pathway, and supplementary transport routes of Se into the brain via 
      low molecular weight Se-species. Additionally, the potential role of Se and 
      selenoproteins in the BBB, BCB, and neurovascular unit (NVU) is discussed. 
      Finally, the perspectives regarding investigating the role of Se and 
      selenoproteins in the gut-brain axis are outlined.
CI  - Copyright (c) 2021 Solovyev, Drobyshev, Blume and Michalke.
FAU - Solovyev, Nikolay
AU  - Solovyev N
AD  - Institute of Technology Sligo, Sligo, Ireland.
FAU - Drobyshev, Evgenii
AU  - Drobyshev E
AD  - Institut fur Ernahrungswissenschaft, Universitat Potsdam, Potsdam, Germany.
FAU - Blume, Bastian
AU  - Blume B
AD  - Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich - German 
      Research Center for Environmental Health (GmbH), Neuherberg, Germany.
FAU - Michalke, Bernhard
AU  - Michalke B
AD  - Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich - German 
      Research Center for Environmental Health (GmbH), Neuherberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210205
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7892976
OTO - NOTNLM
OT  - LRP8
OT  - blood-brain barrier
OT  - blood-cerebrospinal fluid barrier
OT  - brain-gut axis
OT  - low molecular weight selenium species
OT  - selenium
OT  - selenium transport
OT  - selenoprotein P
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/23 06:00
MHDA- 2021/02/23 06:01
PMCR- 2021/01/01
CRDT- 2021/02/22 05:52
PHST- 2020/11/16 00:00 [received]
PHST- 2021/01/20 00:00 [accepted]
PHST- 2021/02/22 05:52 [entrez]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/02/23 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.630016 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Feb 5;15:630016. doi: 10.3389/fnins.2021.630016. eCollection 
      2021.