PMID- 33613317
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210223
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults.
PG  - 625950
LID - 10.3389/fphys.2021.625950 [doi]
LID - 625950
AB  - The study aimed to examine sex-specific associations between objectively measured 
      sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when 
      considering the moderating impact of physical activity (PA). Accelerometer-based 
      monitoring of sedentary patterns and PA was conducted in a population of older 
      men (n = 83; age: 67.4 +/- 1.5; height: 178.7 +/- 6.6 cm; weight: 80.9 +/- 10.6 kg) and 
      women (n = 146; age: 67.4 +/- 1.6; height: 164.2 +/- 6.1 cm; weight: 64.6 +/- 10.1 kg) 
      aged 65-70. Blood samples were collected for the assessment of the inflammatory 
      biomarkers C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, 
      IL-18, and monocyte chemoattractant protein-1 (MCP-1). Data were analyzed using 
      multiple linear regression models. Total and bouts of >/=10 min of sedentary time 
      were inversely associated with the anti-inflammatory marker IL-10 in older men 
      (accumulated sedentary time: beta = -0.116; bouts: beta = -0.099; all p < 0.05). 
      Associations were independent of moderate-to-vigorous physical activity (MVPA) 
      and total PA volume. In women, total and bouts of >/=10 min of sedentary time were 
      detrimentally associated with the pro-inflammatory marker fibrinogen (accumulated 
      sedentary time: beta = -0.130; bouts: beta = -0.085; all p < 0.05). Associations 
      remained between accumulated sedentary time and fibrinogen when adjusting for 
      MVPA and total PA volume. This study highlights sex-specific routes by which 
      sedentary patterns impact on pro- and anti-inflammatory biomarkers in older 
      adults. The findings support efforts to promote accumulation of time spent in PA 
      at the expense of time in sedentary pursuits on low-grade inflammation in older 
      men and women.
CI  - Copyright (c) 2021 Bergens, Nilsson, Papaioannou and Kadi.
FAU - Bergens, Oscar
AU  - Bergens O
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
FAU - Nilsson, Andreas
AU  - Nilsson A
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
FAU - Papaioannou, Konstantinos-Georgios
AU  - Papaioannou KG
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
FAU - Kadi, Fawzi
AU  - Kadi F
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20210205
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC7892961
OTO - NOTNLM
OT  - aging
OT  - inflammatory biomarkers
OT  - metabolic health
OT  - physical activity
OT  - sedentary behaviors
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/23 06:00
MHDA- 2021/02/23 06:01
PMCR- 2021/02/05
CRDT- 2021/02/22 05:53
PHST- 2020/11/11 00:00 [received]
PHST- 2021/01/15 00:00 [accepted]
PHST- 2021/02/22 05:53 [entrez]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/02/23 06:01 [medline]
PHST- 2021/02/05 00:00 [pmc-release]
AID - 10.3389/fphys.2021.625950 [doi]
PST - epublish
SO  - Front Physiol. 2021 Feb 5;12:625950. doi: 10.3389/fphys.2021.625950. eCollection 
      2021.