PMID- 33613481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210223
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 12
DP  - 2021
TI  - Characterization of the Oral Microbiome of Medicated Type-2 Diabetes Patients.
PG  - 610370
LID - 10.3389/fmicb.2021.610370 [doi]
LID - 610370
AB  - Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that is becoming a 
      significant global health care problem. Several studies have shown that people 
      with diabetes are more susceptible to oral problems, such as periodontitis and, 
      although the causes are still inconclusive, oral microbiota is considered to play 
      a major role in oral health. This study aimed to characterize the oral microbiome 
      of a sample representing T2DM patients from Portugal and exploit potential 
      associations between some microorganisms and variables like teeth brushing, 
      smoking habits, average blood sugar levels, medication and nutrient intake. By 
      sequencing the hypervariable regions V3-V4 of the 16S rRNA gene in 50 individuals 
      belonging to a group of diabetes patients and a control group, we found a total 
      of 232 taxa, from which only 65% were shared between both groups. No differences 
      were found in terms of alpha and beta diversity between categories. We did not 
      find significant differences in the oral microbiome profiles of control and 
      diabetes patients. Only the class Synergistia and the genus TG5, which are 
      related to periodontitis, were statistically more frequent in the control group. 
      The similar microbiome profiles of medicated diabetics and the control group 
      indicates that the relationship between the T2DM and the oral microbiome might be 
      more related to either the lifestyle/diet rather than diabetes per se. Moreover, 
      this study provides, for the first time, insights into the oral microbiome of a 
      population with a high prevalence of diabetes.
CI  - Copyright (c) 2021 Almeida-Santos, Martins-Mendes, Gaya-Vidal, Perez-Pardal and 
      Beja-Pereira.
FAU - Almeida-Santos, Ana
AU  - Almeida-Santos A
AD  - Centro de Investigacao em Biodiversidade e Recursos Geneticos (CIBIO-UP), InBIO, 
      Universidade do Porto, Porto, Portugal.
AD  - Department of Geosciences, Environment and Spatial Planning (DGAOT), Faculty of 
      Sciences, University of Porto, Porto, Portugal.
FAU - Martins-Mendes, Daniela
AU  - Martins-Mendes D
AD  - Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia/Espinho EPE, 
      Vila Nova de Gaia, Portugal.
AD  - Diabetic Foot Clinic, Endocrinology, Diabetes and Metabolism Department, Centro 
      Hospitalar de Vila Nova de Gaia/Espinho EPE, Vila Nova de Gaia, Portugal.
AD  - Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, 
      Portugal.
AD  - i3S-Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Porto, 
      Portugal.
FAU - Gaya-Vidal, Magdalena
AU  - Gaya-Vidal M
AD  - Centro de Investigacao em Biodiversidade e Recursos Geneticos (CIBIO-UP), InBIO, 
      Universidade do Porto, Porto, Portugal.
FAU - Perez-Pardal, Lucia
AU  - Perez-Pardal L
AD  - Centro de Investigacao em Biodiversidade e Recursos Geneticos (CIBIO-UP), InBIO, 
      Universidade do Porto, Porto, Portugal.
FAU - Beja-Pereira, Albano
AU  - Beja-Pereira A
AD  - Centro de Investigacao em Biodiversidade e Recursos Geneticos (CIBIO-UP), InBIO, 
      Universidade do Porto, Porto, Portugal.
AD  - Department of Geosciences, Environment and Spatial Planning (DGAOT), Faculty of 
      Sciences, University of Porto, Porto, Portugal.
AD  - Faculty of Sciences, Sustainable Agrifood Production Research Centre 
      (GreenUPorto), University of Porto, Porto, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20210205
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC7892904
OTO - NOTNLM
OT  - 16S rRNA gene sequencing
OT  - Portugal
OT  - microbiota
OT  - next-generation sequencing
OT  - oral hygiene
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/23 06:00
MHDA- 2021/02/23 06:01
PMCR- 2021/02/05
CRDT- 2021/02/22 05:53
PHST- 2020/09/25 00:00 [received]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/02/22 05:53 [entrez]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/02/23 06:01 [medline]
PHST- 2021/02/05 00:00 [pmc-release]
AID - 10.3389/fmicb.2021.610370 [doi]
PST - epublish
SO  - Front Microbiol. 2021 Feb 5;12:610370. doi: 10.3389/fmicb.2021.610370. 
      eCollection 2021.