PMID- 33613654
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210223
IS  - 1671-5411 (Print)
IS  - 1671-5411 (Linking)
VI  - 18
IP  - 1
DP  - 2021 Jan 28
TI  - Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: 
      analysis of a large national database.
PG  - 1-9
LID - 10.11909/j.issn.1671-5411.2021.01.006 [doi]
AB  - OBJECTIVE: In patients undergoing cardiac surgery, reduced preoperative ejection 
      fraction (EF) and senior age are associated with a worse outcome. As most outcome 
      data available for these patients are mainly from Western surgical populations 
      involving specific surgery types, our aim is to evaluate the real-world 
      characteristics and perioperative outcomes of surgery in senior-aged heart 
      failure patients with reduced EF across a broad range cardiac surgeries. METHODS: 
      Data were obtained from the China Heart Failure Surgery Registry (China-HFSR) 
      database, a nationwide multicenter registry study in mainland China. Multiple 
      variable regression analysis was performed in patients over 75 years old to 
      identify risk factors associated with mortality. RESULTS: From 2012 to 2017, 578 
      senior-aged (> 75 years) patients were enrolled in China HFSR, 21.1% of whom were 
      female. Isolated coronary bypass grafting (CABG) were performed in 71.6% of 
      patients, 10.1% of patients underwent isolated valve surgery and 8.7% received 
      CABG combined with valve surgery. In-hospital mortality was 10.6%, and the major 
      complication rate was 17.3%. Multivariate analysis identified diabetes mellitus 
      (odds ratio (OR) = 1.985), increased creatinine (OR = 1.007), New York Heart 
      Association (NYHA) Class III (OR = 1.408), NYHA class IV (OR = 1.955), 
      cardiogenic shock (OR, 6.271), and preoperative intra-aortic balloon pump 
      insertion (OR = 3.426) as independent predictors of in-hospital mortality. 
      CONCLUSIONS: In senior-aged patients, preoperative evaluation should be carefully 
      performed, and strict management of reversible factors needs more attention. 
      Senior-aged patients commonly have a more severe disease status combined with 
      more frequent comorbidities, which may lead to a high risk in mortality.
CI  - Copyright and License information: Journal of Geriatric Cardiology 2021.
FAU - Tang, Han-Wei
AU  - Tang HW
AD  - Department of Cardiovascular Surgery, National Center for Cardiovascular 
      Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Chen, Kai
AU  - Chen K
AD  - Department of Cardiovascular Surgery, National Center for Cardiovascular 
      Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Hou, Jian-Feng
AU  - Hou JF
AD  - Department of Cardiovascular Surgery, National Center for Cardiovascular 
      Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Huang, Xiao-Hong
AU  - Huang XH
AD  - Department of Special Medical Treatment Center, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union 
      Medical College, Beijing, China.
FAU - Liu, Sheng
AU  - Liu S
AD  - Department of Cardiovascular Surgery, National Center for Cardiovascular 
      Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Ma, Han-Ping
AU  - Ma HP
AD  - Department of Cardiovascular Surgery, National Center for Cardiovascular 
      Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Hu, Sheng-Shou
AU  - Hu SS
AD  - Department of Cardiovascular Surgery, National Center for Cardiovascular 
      Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Geriatr Cardiol
JT  - Journal of geriatric cardiology : JGC
JID - 101237881
PMC - PMC7868914
EDAT- 2021/02/23 06:00
MHDA- 2021/02/23 06:01
PMCR- 2021/01/28
CRDT- 2021/02/22 05:54
PHST- 2021/02/22 05:54 [entrez]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/02/23 06:01 [medline]
PHST- 2021/01/28 00:00 [pmc-release]
AID - jgc-18-1-1 [pii]
AID - 10.11909/j.issn.1671-5411.2021.01.006 [doi]
PST - ppublish
SO  - J Geriatr Cardiol. 2021 Jan 28;18(1):1-9. doi: 
      10.11909/j.issn.1671-5411.2021.01.006.