PMID- 33613883
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 11
IP  - 4
DP  - 2020 Jul-Aug
TI  - The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the 
      Hippocampus of Male Rats.
PG  - 457-464
LID - 10.32598/bcn.9.10.420 [doi]
AB  - INTRODUCTION: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or 
      ecstasy causes memory impairment, whereas neurogenesis improves memory and 
      learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the 
      hippocampus of male rats. METHODS: Adult male Wistar rats received 
      Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, 
      sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the 
      immunohistochemistry analyses. RESULTS: MDMA reduced the expressions of nestin, 
      Sox2, and NeuroD compared with the control groups. The reduction in NeuroD 
      expression was age-related. CONCLUSION: MDMA possibly has negative effects on 
      neurogenesis, which specifically results from impaired survival of newborn cells.
CI  - Copyright(c) 2020 Iranian Neuroscience Society.
FAU - Soleimani Asl, Sara
AU  - Soleimani Asl S
AUID- ORCID: 0000-0003-1518-3308
AD  - Endometrium and Endometriosis Research Centre, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Ghasemi Moravej, Fahimeh
AU  - Ghasemi Moravej F
AUID- ORCID: 0000-0003-3878-3082
AD  - Endometrium and Endometriosis Research Centre, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Kowsari, Golshad
AU  - Kowsari G
AD  - School of Advanced Technologies in Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Farhadi, Mohammad Hassan
AU  - Farhadi MH
AUID- ORCID: 0000-0003-0648-7182
AD  - Researcher of Subsance Abuse and Dependence Research Center, University of Social 
      Welfare and Rehabilitation Sciences, Tehran, Iran.
FAU - Pourhaydar, Bagher
AU  - Pourhaydar B
AUID- ORCID: 0000-0003-3075-9889
AD  - Department of Anatomy, Neurophysiology Research Center, School of Medicine, Urmia 
      University of Medical Sciences, Urmia, Iran.
FAU - Ghasemi Hamidabadi, Hatef
AU  - Ghasemi Hamidabadi H
AUID- ORCID: 0000-0002-2178-6503
AD  - Department of Anatomy and Cell Biology, School of Medicine, Mazandaran University 
      of Medical Sciences, Sari, Iran.
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
AUID- ORCID: 0000-0002-2673-2715
AD  - Department of Anatomy, Cellular and Molecular Research Center, School of 
      Medicine, Iran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200701
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC7878031
OTO - NOTNLM
OT  - Hippocampus
OT  - N-Methyl-3,4-methylenedioxyamphetamine
OT  - Nestin
OT  - NeuroD Protein
OT  - Sox2 Protein
COIS- Conflict of interest The authors declared no conflict of interest.
EDAT- 2021/02/23 06:00
MHDA- 2021/02/23 06:01
PMCR- 2020/07/01
CRDT- 2021/02/22 05:55
PHST- 2018/06/27 00:00 [received]
PHST- 2018/07/10 00:00 [revised]
PHST- 2019/02/19 00:00 [accepted]
PHST- 2021/02/22 05:55 [entrez]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/02/23 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - BCN-11-457 [pii]
AID - 10.32598/bcn.9.10.420 [doi]
PST - ppublish
SO  - Basic Clin Neurosci. 2020 Jul-Aug;11(4):457-464. doi: 10.32598/bcn.9.10.420. Epub 
      2020 Jul 1.