PMID- 3361431
OWN - NLM
STAT- MEDLINE
DCOM- 19880608
LR  - 20190710
IS  - 0022-3549 (Print)
IS  - 0022-3549 (Linking)
VI  - 77
IP  - 2
DP  - 1988 Feb
TI  - Definitions and applications of mean transit and residence times in reference to 
      the two-compartment mammillary plasma clearance model.
PG  - 157-65
AB  - The mean transit time (MTT) and the mean residence time (MRT) values of a linear 
      two-compartment plasma clearance model were evaluated using definitions 
      originally proposed by Rescigno and Gurpide. The MRT of the total body (MRTB) can 
      be viewed as comprising the MRT in the central compartment (MRTC) and the MRT in 
      the peripheral tissue compartment (MRTT). The MTT and MRT of each compartment can 
      be envisioned as the average interval of time spent by a drug particle during a 
      single passage and in all passages through it. Hence, the MRT is the product of 
      MTT and the mean number of passages of a drug particle through the central (R + 
      1) or tissue (R) compartments. Physiologically, each MTT parameter is related to 
      its apparent volume divided by all its clearance processes, reversible and 
      irreversible (if any exist). Each MRT parameter is related to its apparent volume 
      divided by only the sum of irreversible exit clearances. Applications of the five 
      MTT/MRT parameters were made to disposition data for digoxin and gentamicin to 
      assess their use as indicators of tissue persistency. This report provides 
      additional physiological and pharmacokinetic insights into the disposition 
      properties of drugs and reconciles various treatments of the two-compartment 
      model using rate constants, volume/clearance terms, and transit/residence times.
FAU - Kong, A N
AU  - Kong AN
AD  - Department of Pharmaceutics, School of Pharmacy, State University of New York at 
      Buffalo 14260.
FAU - Jusko, W J
AU  - Jusko WJ
LA  - eng
GR  - 20852/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Metabolic Clearance Rate
MH  - *Models, Biological
MH  - Models, Theoretical
MH  - Pharmaceutical Preparations
MH  - Pharmacokinetics
MH  - Tissue Distribution
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - S0022-3549(15)47624-5 [pii]
AID - 10.1002/jps.2600770213 [doi]
PST - ppublish
SO  - J Pharm Sci. 1988 Feb;77(2):157-65. doi: 10.1002/jps.2600770213.