PMID- 33614896 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240330 IS - 2352-8737 (Electronic) IS - 2352-8737 (Linking) VI - 7 IP - 1 DP - 2021 TI - Race/ethnicity and gender modify the association between diet and cognition in U.S. older adults: National Health and Nutrition Examination Survey 2011-2014. PG - e12128 LID - 10.1002/trc2.12128 [doi] LID - e12128 AB - INTRODUCTION: It is unclear whether the association between Mediterranean-type Diet (MeDi) and cognition is similar across different racial/ethnic groups or between women and men. METHODS: The current study included 2435 participants (>/=60 years of age) of the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Linear regression models were applied to examine the association between diet and cognition, adjusted for multiple demographic variables. Interaction between MeDi and race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, other), and between MeDi and gender, were examined, followed by stratified analyses. RESULTS: One score increase in MeDi was associated with 0.039 (95%confidence interval [CI] = 0.016-0.062) higher global cognitive z-score. Significant associations between MeDi and global cognition and between MeDi and immediate recall were found in the non-Hispanic Whites only (P-interaction = 0.057 and 0.059, respectively). MeDi was associated with increased score of animal fluency score in men but not in women (P-interaction = 0.082). DISCUSSION: The positive association between MeDi and cognition might be dependent on race/ethnicity and gender. CI - (c) 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. FAU - Gu, Yian AU - Gu Y AD - Taub Institute for Research in Alzheimer's Disease and the Aging Brain Columbia University New York New York USA. AD - Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York New York USA. AD - Gertrude H. Sergievsky Center Columbia University New York New York USA. AD - Department of Epidemiology Joseph P. Mailman School of Public Health Columbia University New York New York USA. FAU - Guo, Jing AU - Guo J AD - Taub Institute for Research in Alzheimer's Disease and the Aging Brain Columbia University New York New York USA. FAU - Moshfegh, Alanna J AU - Moshfegh AJ AD - Beltsville Human Nutrition Research Center Agricultural Research Service USDA Beltsville Maryland USA. LA - eng GR - R01 AG059013/AG/NIA NIH HHS/United States GR - R01 AG061008/AG/NIA NIH HHS/United States GR - R56 AG060156/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20210214 PL - United States TA - Alzheimers Dement (N Y) JT - Alzheimer's & dementia (New York, N. Y.) JID - 101650118 PMC - PMC7882526 OTO - NOTNLM OT - NHANES OT - aging OT - cognition OT - diet OT - epidemiology COIS- All authors have nothing to disclose. EDAT- 2021/02/23 06:00 MHDA- 2021/02/23 06:01 PMCR- 2021/02/14 CRDT- 2021/02/22 05:58 PHST- 2020/08/03 00:00 [received] PHST- 2020/10/20 00:00 [revised] PHST- 2020/11/25 00:00 [accepted] PHST- 2021/02/22 05:58 [entrez] PHST- 2021/02/23 06:00 [pubmed] PHST- 2021/02/23 06:01 [medline] PHST- 2021/02/14 00:00 [pmc-release] AID - TRC212128 [pii] AID - 10.1002/trc2.12128 [doi] PST - epublish SO - Alzheimers Dement (N Y). 2021 Feb 14;7(1):e12128. doi: 10.1002/trc2.12128. eCollection 2021.