PMID- 33615447
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20231107
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 127
IP  - 11
DP  - 2021 Jun 1
TI  - Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell 
      carcinoma and esophageal squamous cell carcinoma in the NIH-AARP Diet and Health 
      Study cohort.
PG  - 1871-1879
LID - 10.1002/cncr.33427 [doi]
AB  - BACKGROUND: Prior studies have suggested that gastroesophageal reflux disease 
      (GERD) may be associated with risk of squamous cancers of the larynx and 
      esophagus; however, most of these studies have had methodological limitations or 
      insufficient control for potential confounders. METHODS: We prospectively 
      examined the association between GERD and esophageal adenocarcinoma (EADC), 
      esophageal squamous cell carcinoma (ESCC), and laryngeal squamous cell carcinoma 
      (LSCC) in 490,605 participants of the NIH-AARP Diet and Health Study cohort who 
      were 50-71 years of age at baseline. Exposure to risk factors were obtained from 
      the baseline questionnaire. GERD diagnosis was extracted among eligible 
      participants via linkage to Medicare diagnoses codes and then multiply imputed 
      for non-Medicare-eligible participants. Hazard ratios (HRs) and 95% CIs of GERD 
      were computed using Cox regression. RESULTS: From 1995 to 2011, we accrued 931 
      cases of EADC, 876 cases of LSCC, and 301 cases of ESCC in this cohort and 
      estimated multivariable-adjusted HRs of 2.23 (95% CI, 1.72-2.90), 1.91 (95% CI, 
      1.24-2.94), and 1.99 (95% CI, 1.39-2.84) for EADC, LSCC, and ESCC, respectively. 
      The associations were independent of sex, smoking status, alcohol intake, and 
      follow-up time periods. We estimated that among the general population in the 
      United States, 22.04% of people aged 50-71 years suffered from GERD. Using risk 
      factor distributions for the United States from national survey data, 16.92% of 
      LSCC cases and 17.32% of ESCC cases among individuals aged 50-71 years were 
      estimated to be associated with GERD. CONCLUSION: GERD is a common 
      gastrointestinal disorder, but future prospective studies are needed to replicate 
      our findings. If replicated, they may inform clinical surveillance of GERD 
      patients and suggest new avenues for prevention of these malignancies.
CI  - (c) 2021 American Cancer Society.
FAU - Wang, Shao-Ming
AU  - Wang SM
AUID- ORCID: 0000-0003-0420-2833
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
AD  - Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, 
      National Cancer Institute, National Institutes of Health, Rockville, Maryland.
FAU - Freedman, Neal D
AU  - Freedman ND
AD  - Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, 
      National Cancer Institute, National Institutes of Health, Rockville, Maryland.
FAU - Katki, Hormuzd A
AU  - Katki HA
AD  - Biostatistics Branch, Division of Cancer Epidemiology & Genetics, National Cancer 
      Institute, National Institutes of Health, Bethesda, Maryland.
FAU - Matthews, Charles
AU  - Matthews C
AD  - Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, 
      National Cancer Institute, National Institutes of Health, Rockville, Maryland.
FAU - Graubard, Barry I
AU  - Graubard BI
AD  - Biostatistics Branch, Division of Cancer Epidemiology & Genetics, National Cancer 
      Institute, National Institutes of Health, Bethesda, Maryland.
FAU - Kahle, Lisa L
AU  - Kahle LL
AD  - Information Management Services Inc, Calverton, Maryland.
FAU - Abnet, Christian C
AU  - Abnet CC
AD  - Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, 
      National Cancer Institute, National Institutes of Health, Rockville, Maryland.
LA  - eng
GR  - ZIA CP010196/ImNIH/Intramural NIH HHS/United States
GR  - Intramural Research Program/National Cancer Institute, National Institutes of 
      Health/
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20210222
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - Adenocarcinoma Of Esophagus
SB  - IM
MH  - Adenocarcinoma/epidemiology
MH  - Aged
MH  - *Esophageal Neoplasms/epidemiology
MH  - *Esophageal Squamous Cell Carcinoma/epidemiology
MH  - *Gastroesophageal Reflux/epidemiology
MH  - *Head and Neck Neoplasms/epidemiology
MH  - Humans
MH  - Medicare
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - *Squamous Cell Carcinoma of Head and Neck/epidemiology
MH  - United States/epidemiology
PMC - PMC8406665
MID - NIHMS1732215
OTO - NOTNLM
OT  - NIH-AARP cohort
OT  - esophageal squamous cell carcinoma
OT  - gastroesophageal reflux disease (GERD)
OT  - laryngeal squamous cell carcinoma
OT  - prospective analysis
COIS- Conflicts of interests All authors declare no potential conflicts of interests.
EDAT- 2021/02/23 06:00
MHDA- 2021/12/31 06:00
PMCR- 2022/06/01
CRDT- 2021/02/22 06:02
PHST- 2020/11/30 00:00 [revised]
PHST- 2020/10/14 00:00 [received]
PHST- 2020/12/16 00:00 [accepted]
PHST- 2021/02/23 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
PHST- 2021/02/22 06:02 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.1002/cncr.33427 [doi]
PST - ppublish
SO  - Cancer. 2021 Jun 1;127(11):1871-1879. doi: 10.1002/cncr.33427. Epub 2021 Feb 22.