PMID- 33616301 OWN - NLM STAT- MEDLINE DCOM- 20211102 LR - 20211204 IS - 2328-9503 (Electronic) IS - 2328-9503 (Linking) VI - 8 IP - 3 DP - 2021 Mar TI - Angiopoietin-like protein 4 and clinical outcomes in ischemic stroke patients. PG - 687-695 LID - 10.1002/acn3.51319 [doi] AB - AIMS: Angiopoietin-like protein 4 (ANGPTL-4) had been reported to be associated with the risk of ischemic stroke, but its prognostic value remained unclear. The aim of this study was to investigate the association between plasma ANGPTL-4 concentrations and prognosis of ischemic stroke. METHODS: Baseline plasma ANGPTL-4 concentrations were measured in 3379 acute ischemic stroke patients. The primary outcome was a combination of death or major disability (modified Rankin Scale score, >/=3) at 3 months after ischemic stroke. RESULTS: At 3 months after ischemic stroke, 850 (26.16%) participants experienced major disability or died (750 major disabilities and 100 deaths). After adjusting for important covariates, odds ratios for the highest tertile of plasma ANGPTL-4 concentrations were 1.59 (1.22-2.06) for primary outcome, 1.53 (1.18-1.97) for major disability, and 2.03 (1.03-4.00) for death when compared with the lowest tertile of plasma ANGPTL-4 concentrations. For 1-SD increase in log-ANGPTL-4 concentrations (0.44 ng/mL), the adjusted odds ratios were 1.24 (1.11-1.38), 1.14 (1.03-1.27), and 1.72 (1.32-2.23), respectively. Adding ANGPTL-4 to a model containing conventional risk factors improved risk prediction for composite outcome of death and major disability. CONCLUSION: Higher plasma ANGPTL-4 concentration was associated with poor prognosis in acute ischemic stroke patients, suggesting that ANGPTL-4 might be a prognostic marker for ischemic stroke. CI - (c) 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. FAU - Zheng, Xiaowei AU - Zheng X AUID- ORCID: 0000-0002-4842-4852 AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Shen, Suwen AU - Shen S AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Wang, Aili AU - Wang A AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Zhu, Zhengbao AU - Zhu Z AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. AD - Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA. FAU - Peng, Yanbo AU - Peng Y AD - Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Tangshan, China. FAU - Peng, Hao AU - Peng H AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Zhong, Chongke AU - Zhong C AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Guo, Daoxia AU - Guo D AUID- ORCID: 0000-0002-4537-0705 AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Xu, Tan AU - Xu T AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - Chen, Jing AU - Chen J AD - Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA. AD - Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA. FAU - Ju, Zhong AU - Ju Z AD - Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Tongliao, China. FAU - Geng, Deqin AU - Geng D AD - Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China. FAU - Zhang, Yonghong AU - Zhang Y AD - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. FAU - He, Jiang AU - He J AD - Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA. AD - Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210222 PL - United States TA - Ann Clin Transl Neurol JT - Annals of clinical and translational neurology JID - 101623278 RN - 0 (ANGPTL4 protein, human) RN - 0 (Angiopoietin-Like Protein 4) RN - 0 (Biomarkers) SB - IM MH - Acute Disease MH - Aged MH - Angiopoietin-Like Protein 4/*blood MH - Biomarkers/blood MH - Female MH - Follow-Up Studies MH - Humans MH - Ischemic Stroke/*blood/*diagnosis/mortality/therapy MH - Male MH - Middle Aged MH - *Outcome Assessment, Health Care MH - Prognosis PMC - PMC7951112 COIS- The authors declare that they have no competing interests. EDAT- 2021/02/23 06:00 MHDA- 2021/11/03 06:00 PMCR- 2021/02/22 CRDT- 2021/02/22 09:21 PHST- 2020/10/06 00:00 [received] PHST- 2021/01/18 00:00 [revised] PHST- 2021/01/26 00:00 [accepted] PHST- 2021/02/23 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] PHST- 2021/02/22 09:21 [entrez] PHST- 2021/02/22 00:00 [pmc-release] AID - ACN351319 [pii] AID - 10.1002/acn3.51319 [doi] PST - ppublish SO - Ann Clin Transl Neurol. 2021 Mar;8(3):687-695. doi: 10.1002/acn3.51319. Epub 2021 Feb 22.