PMID- 33618927
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220204
IS  - 1535-6345 (Electronic)
IS  - 0147-0272 (Linking)
VI  - 45
IP  - 5
DP  - 2021 Oct
TI  - Case report: Delayed retinoblastoma relapse in a lymph node after 9 years of 
      complete remission.
PG  - 100703
LID - S0147-0272(20)30226-9 [pii]
LID - 10.1016/j.currproblcancer.2020.100703 [doi]
AB  - Retinoblastoma (RB) is the most common primary intraocular malignancy of 
      childhood. Recurrence of RB often occurs within 6 months to 1 year after the end 
      of treatment. Orbital tissue is the most common site of recurrence in children 
      who have undergone enucleation; other sites include the central nervous system, 
      bone, bone marrow, lymph nodes, and other organs. Here, we describe an adolescent 
      girl who presented with RB recurrence and metastasis in a distant lymph node 
      after 9 years of complete remission. The tumor was an incidental finding during a 
      routine examination and was misdiagnosed as lymphadenitis. After histopathologic 
      examination of an aspiration biopsy sample, the correct diagnosis of recurrent 
      metastatic RB was made. Systemic chemotherapy and surgical excision were 
      provided; the patient remained tumor-free during the 6-month follow-up period. RB 
      often relapses within 1 year after treatment; orbital tissue is the most common 
      site of recurrence. However, our patient's case was unique in terms of delayed 
      relapse and the presence of a single metastatic site; these findings may provide 
      new insights into the behavior of RB. Furthermore, this case report indicates the 
      need for lifelong follow-up of children with RB. Oncologists should be vigilant 
      when treating patients with a history of RB, because complete remission does not 
      mean complete safety; long-term recurrence and metastasis may occur. Lifelong 
      follow-up is necessary for children with RB. Complete remission might be achieved 
      after active and standardized treatment.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Gu, Huali
AU  - Gu H
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Wang, Yizhuo
AU  - Wang Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Huang, Dongsheng
AU  - Huang D
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China. Electronic address: hds5180@sina.com.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Weiling
AU  - Zhang W
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Hu, Huimin
AU  - Hu H
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Pinwei
AU  - Zhang P
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Yi, You
AU  - Yi Y
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Chen, Lin
AU  - Chen L
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Han, Siyu
AU  - Han S
AD  - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210108
PL  - United States
TA  - Curr Probl Cancer
JT  - Current problems in cancer
JID - 7702986
SB  - IM
MH  - Child, Preschool
MH  - China
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis/diagnostic imaging/*pathology
MH  - Remission Induction
MH  - Retinal Neoplasms/diagnostic imaging/*pathology/surgery
MH  - Retinoblastoma/diagnostic imaging/*pathology/surgery
MH  - Time
OTO - NOTNLM
OT  - Adolescence
OT  - Complete remission
OT  - Metastasis
OT  - Recurrence
OT  - Retinoblastoma (RB)
EDAT- 2021/02/24 06:00
MHDA- 2022/02/05 06:00
CRDT- 2021/02/23 05:44
PHST- 2020/10/28 00:00 [received]
PHST- 2020/12/08 00:00 [revised]
PHST- 2020/12/15 00:00 [accepted]
PHST- 2021/02/24 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2021/02/23 05:44 [entrez]
AID - S0147-0272(20)30226-9 [pii]
AID - 10.1016/j.currproblcancer.2020.100703 [doi]
PST - ppublish
SO  - Curr Probl Cancer. 2021 Oct;45(5):100703. doi: 
      10.1016/j.currproblcancer.2020.100703. Epub 2021 Jan 8.