PMID- 33621749
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 201
DP  - 2021 May
TI  - Surface modification of polyurethane with eptifibatide-loaded degradable 
      nanoparticles reducing risk of blood coagulation.
PG  - 111624
LID - S0927-7765(21)00068-0 [pii]
LID - 10.1016/j.colsurfb.2021.111624 [doi]
AB  - The main purpose of the work was to develop a drug releasing coatings on the 
      surface of medical devices exposed to blood flow, what should enable effective 
      inhibition of blood coagulation process. As a part of the work, the process of 
      encapsulating the anticoagulant drug eptifibatide (EPT) in 
      poly(DL-lactic-co-glycolic acid) (PLGA) nanoparticles was developed. EPT 
      encapsulation efficiency was 29.1 +/- 2.1%, while the EPT loading percentage in the 
      nanoparticles was 4.2 +/- 0.3%. The PLGA nanoparticles were suspended in a 
      polyanion solution (hyaluronic acid (HA)) and deposited on the surface-treated 
      thermoplastic polyurethane (TPU) by a layer-by-layer method. As a polycation 
      poly-L-lysine (PLL) was used. The influence of released EPT on the activation of 
      the coagulation system was analyzed using dynamic blood tester. Performed 
      experiments show an effective delivery of the drug to the bloodstream and low 
      risk of platelets (membrane receptor) activation. The dynamic blood test process, 
      including its physical phenomenon, was described using numerical methods, i.e. a 
      finite volume cone-and-plate test model as well as non-Newtonian blood models. 
      The values of shear stress and blood flow velocity under the fast-rotating cone 
      were computed applying boundary conditions of cylinder wall imitating 
      blood-nanomaterial interaction. Implementing boundary conditions as initial shear 
      stress values of bottom cylinder wall resulted in the increase of shear stress in 
      blood under rotating cone. The developed system combining drug eluting polymeric 
      nanoparticles with the polyelectrolyte "layer-by-layer" coating can be easily 
      introduced to medical implants of various shape, with the advantages of 
      resorbable drug carriers allowing for local and controllable delivery of 
      anti-thrombogenic drugs.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Reczynska, Katarzyna
AU  - Reczynska K
AD  - AGH University of Science and Technology, Faculty of Materials Science and 
      Ceramics, Al. Mickiewicza 30, 30-059 Krakow, Poland.
FAU - Major, Roman
AU  - Major R
AD  - Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 
      Reymonta st., 30-059 Cracow, Poland.
FAU - Kopernik, Magdalena
AU  - Kopernik M
AD  - AGH University of Science and Technology, Faculty of Metals Engineering and 
      Industrial Computer Science, Al. Mickiewicza 30, 30-059 Krakow, Poland. 
      Electronic address: kopernik@agh.edu.pl.
FAU - Pamula, Elzbieta
AU  - Pamula E
AD  - AGH University of Science and Technology, Faculty of Materials Science and 
      Ceramics, Al. Mickiewicza 30, 30-059 Krakow, Poland.
FAU - Imbir, Gabriela
AU  - Imbir G
AD  - Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 
      Reymonta st., 30-059 Cracow, Poland.
FAU - Plutecka, Hanna
AU  - Plutecka H
AD  - Department of Internal Medicine, Jagiellonian University Medical College, 8 
      Skawinska st., 31-066 Cracow, Poland.
FAU - Bruckert, Franz
AU  - Bruckert F
AD  - Laboratoire des Materiaux et du Genie Physique - UMR 5628, 3 parvis Louis Neel, 
      Grenoble Cedex 1, France.
FAU - Surmiak, Marcin
AU  - Surmiak M
AD  - Department of Internal Medicine, Jagiellonian University Medical College, 8 
      Skawinska st., 31-066 Cracow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210213
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Drug Carriers)
RN  - 0 (Polyurethanes)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - NA8320J834 (Eptifibatide)
SB  - IM
MH  - Blood Coagulation
MH  - Drug Carriers
MH  - Eptifibatide
MH  - *Nanoparticles
MH  - Particle Size
MH  - *Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polyurethanes
OTO - NOTNLM
OT  - Blood activation
OT  - Blood coagulation
OT  - Cone-and-plate test
OT  - Eptifibatide
OT  - Nanoparticles
OT  - Poly(DL-lactic-co-glycolic acid) (PLGA)
EDAT- 2021/02/24 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/02/23 20:10
PHST- 2020/10/07 00:00 [received]
PHST- 2021/02/03 00:00 [revised]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/02/24 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/02/23 20:10 [entrez]
AID - S0927-7765(21)00068-0 [pii]
AID - 10.1016/j.colsurfb.2021.111624 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2021 May;201:111624. doi: 
      10.1016/j.colsurfb.2021.111624. Epub 2021 Feb 13.