PMID- 33623872
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210225
IS  - 2536-4553 (Electronic)
IS  - 2148-4902 (Print)
IS  - 2536-4553 (Linking)
VI  - 8
IP  - 1
DP  - 2021
TI  - The relationship of ischemia-modified albumin levels to disease activity scores 
      and HLA-B27 in patients with ankylosing spondylitis.
PG  - 42-48
LID - 10.14744/nci.2020.23590 [doi]
AB  - OBJECTIVE: Recent studies have implicated increased oxidative stress in the 
      pathogenesis of Ankylosing spondylitis (AS). Ischemia-modified albumin (IMA), an 
      altered form of albumin, increases oxidative stress. This study aimed to 
      investigate the relationship between IMA levels and other indicators of disease 
      severity in AS. METHODS: This study included 63 AS patients and 48 healthy 
      controls. Patients were examined for serum lipid profile, C-reactive protein 
      (CRP), complete blood count, Bath Ankylosing Spondylitis Disease Activity Index, 
      human leukocyte antigen (HLA) B27, and treatment regimen. They were categorized 
      based on disease activity, HLA-B27 status, and the drug treatment and compared 
      for IMA levels. RESULTS: The patients had significantly higher IMA levels than 
      controls (p=0.020); among patients, the levels were higher in those with active 
      disease (p=0.001) and positively correlated with the CRP levels. No significant 
      difference was found between the IMA levels of the patients with different 
      HLA-B27 status or treatment method. CONCLUSION: The IMA levels were higher in 
      patients than controls and further increased in patients with active AS. IMA was 
      associated with disease activity and can be used as an inflammatory marker in AS. 
      More comprehensive future studies with a larger sample size may help understand 
      the relationship in greater detail.
CI  - Copyright: (c) 2021 by Istanbul Northern Anatolian Association of Public Hospitals.
FAU - Sertpoyraz, Filiz Meryem
AU  - Sertpoyraz FM
AD  - Department of Physical Medicine and Rehabilitation, Health Science University 
      Izmir Training and Research Hospital, Izmir, Turkey.
FAU - Colak, Ayfer
AU  - Colak A
AD  - Department of Biochemistry, Health Science University Izmir Training and Research 
      Hospital, Izmir, Turkey.
FAU - Dikici, Aylin
AU  - Dikici A
AD  - Department of Physical Medicine and Rehabilitation, Health Science University 
      Izmir Training and Research Hospital, Izmir, Turkey.
FAU - Gunduz, Nihan Erdinc
AU  - Gunduz NE
AD  - Department of Physical Medicine and Rehabilitation, Health Science University 
      Izmir Training and Research Hospital, Izmir, Turkey.
FAU - Aksit, Merve Zeytinli
AU  - Aksit MZ
AD  - Department of Biochemistry, Health Science University Izmir Training and Research 
      Hospital, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201124
PL  - Turkey
TA  - North Clin Istanb
JT  - Northern clinics of Istanbul
JID - 101684520
PMC - PMC7881419
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - disease activity
OT  - ischemia-modified albumin
COIS- Conflict of Interest: No conflict of interest was declared by the authors.
EDAT- 2021/02/25 06:00
MHDA- 2021/02/25 06:01
PMCR- 2020/11/24
CRDT- 2021/02/24 05:45
PHST- 2019/11/29 00:00 [received]
PHST- 2020/06/08 00:00 [accepted]
PHST- 2021/02/24 05:45 [entrez]
PHST- 2021/02/25 06:00 [pubmed]
PHST- 2021/02/25 06:01 [medline]
PHST- 2020/11/24 00:00 [pmc-release]
AID - NCI-8-42 [pii]
AID - 10.14744/nci.2020.23590 [doi]
PST - epublish
SO  - North Clin Istanb. 2020 Nov 24;8(1):42-48. doi: 10.14744/nci.2020.23590. 
      eCollection 2021.