PMID- 33624118
OWN - NLM
STAT- MEDLINE
DCOM- 20211008
LR  - 20211008
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 29
IP  - 9
DP  - 2021 Sep
TI  - Safety of fluoroscopically guided pain procedures in patients receiving cytotoxic 
      chemotherapy: a retrospective analysis.
PG  - 5173-5178
LID - 10.1007/s00520-021-06085-0 [doi]
AB  - PURPOSE: To examine the incidence of bleeding and infectious adverse events (AEs) 
      in patients undergoing interventional, fluoroscopic-guided axial spine procedures 
      to modulate pain. METHODS: Retrospective data of patients undergoing 
      fluoroscopically guided axial spine injections at a single tertiary care medical 
      center Cancer Rehabilitation program in the USA were reviewed. AEs, type of 
      chemotherapy, type of tumor, age, platelet and absolute neutrophil counts (ANC) 
      prior to the procedure, and relevant past medical history were collected. 
      Descriptive statistical analyses were performed. RESULTS: Sixty-three separately 
      identifiable procedures across 28 patients met inclusion criteria. Zero AEs were 
      recorded. Platelet and ANC were generally above the recommended safety threshold, 
      but granulocyte colony stimulating factor was administered prior to four 
      procedures to boost ANC levels. Multiple myeloma was the most common cancer 
      diagnosis (64.3%). Various solid tumors made up the remaining cancer diagnoses. 
      Epidural steroid injections (n=23) and medial branch blocks (n=23) were the most 
      common procedures performed and lumbar (n=35) was the most common location of 
      procedures. Three patients died within 30 days of the procedures but their deaths 
      were not directly attributable to the injections. CONCLUSION: This provides 
      preliminary data to support the safety of injections in patients receiving 
      cytotoxic chemotherapy. Larger, multicenter studies are required before firm 
      conclusions can be drawn.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part 
      of Springer Nature.
FAU - Joyce, Elizabeth
AU  - Joyce E
AD  - Department of Physical Medicine and Rehabilitation, University of Michigan 
      Medical School, Ann Arbor, MI, USA.
FAU - Bakshi, Rishi
AU  - Bakshi R
AD  - Department of Physical Medicine and Rehabilitation, University of Michigan 
      Medical School, Ann Arbor, MI, USA.
FAU - Fediw, Michael
AU  - Fediw M
AD  - Department of Physical Medicine and Rehabilitation, University of Texas 
      Southwestern, Dallas, TX, USA.
FAU - Smith, Sean R
AU  - Smith SR
AUID- ORCID: 0000-0001-9936-8750
AD  - Department of Physical Medicine and Rehabilitation, University of Michigan 
      Medical School, Ann Arbor, MI, USA. srsz@med.umich.edu.
LA  - eng
PT  - Journal Article
DEP - 20210224
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - *Cancer Pain
MH  - Fluoroscopy
MH  - Humans
MH  - Injections, Epidural
MH  - Pain Measurement
MH  - Practice Guidelines as Topic
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cancer pain
OT  - Cancer rehabilitation
OT  - Epidural steroid injection
OT  - Injection safety
OT  - Spine injections
EDAT- 2021/02/25 06:00
MHDA- 2021/10/09 06:00
CRDT- 2021/02/24 05:46
PHST- 2020/10/19 00:00 [received]
PHST- 2021/02/18 00:00 [accepted]
PHST- 2021/02/25 06:00 [pubmed]
PHST- 2021/10/09 06:00 [medline]
PHST- 2021/02/24 05:46 [entrez]
AID - 10.1007/s00520-021-06085-0 [pii]
AID - 10.1007/s00520-021-06085-0 [doi]
PST - ppublish
SO  - Support Care Cancer. 2021 Sep;29(9):5173-5178. doi: 10.1007/s00520-021-06085-0. 
      Epub 2021 Feb 24.