PMID- 33624230
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 37
IP  - 5
DP  - 2021 May
TI  - Echocardiographic assessment of left ventricular filling pressure in patients 
      with acute ST elevation myocardial infarction: an invasive validation study.
PG  - 1587-1594
LID - 10.1007/s10554-020-02138-3 [doi]
AB  - Backgrounds Assessment of left ventricular filling pressure (LVFP) is of clinical 
      importance in patients with ST elevation myocardial infarction (STEMI). Although 
      several echocardiographic parameters are recommended for the assessment of LVFP, 
      validation of these parameters in patients with STEMI is missing. We aimed to 
      investigate the clinical utility of these parameters in acute settings. Methods: 
      We prospectively included consecutive patients with STEMI. LV end-diastolic 
      pressure (LVEDP) was measured following primary PCI and echocardiographic 
      examination was performed within 24 hours. Mean left atrial pressure (mLAP) was 
      calculated both invasively using Yamamoto's formula and non-invasively using 
      Naugeh's formula. Mean LAP was considered increased when exceeded 18 mmHg. 
      Results: Patients were grouped according to LVEDP, group 1(41 patients) and group 
      2(114 patients).There was no significant difference between groups in terms of 
      comorbidities. NT pro-BNP levels (p < 0.001) and peak level of Hs-TnT (p-value: 
      0.002) were significantly higher in group 2. Average E/e' ratio was significantly 
      higher in group 2 (10.19 +/- 3.15 vs. 12.04 +/- 4.83, p: 0.046). Isovolumetric 
      relaxation time was longer in group 2 (p < 0.001) and left atrial volume index 
      (LAVI) was also significantly higher in group 2 (p < 0.001). Regression analyses 
      revealed that septal, lateral and average E/e' ratio, tricuspid regurgitation 
      velocity, LAVI and left ventricular volume are correlated with mLAP. Among group 
      2 patients only 14 Patients fulfilled the increased LVFP criteria suggested by 
      current guidelines. Conclusions Echocardiographic parameters indicating increased 
      LVFP require validation and may need to be modified in patients with STEMI. 
      Moreover, current algorithms underestimate the actual number of patients with 
      increased LVFP.
FAU - Durmaz, Eser
AU  - Durmaz E
AUID- ORCID: 0000-0002-1468-0153
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey. durmazeser@hotmail.com.
FAU - Ikitimur, Baris
AU  - Ikitimur B
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Karadag, Bilgehan
AU  - Karadag B
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Koca, Damla
AU  - Koca D
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Ohtaroglu Tokdil, Kardelen
AU  - Ohtaroglu Tokdil K
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Raimoglu, Utku
AU  - Raimoglu U
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Soysal, Ali Ugur
AU  - Soysal AU
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Incesu, Gunduz
AU  - Incesu G
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Belpinar, Mehmet Semih
AU  - Belpinar MS
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Mutlu, Deniz
AU  - Mutlu D
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
FAU - Yurtseven, Ece
AU  - Yurtseven E
AD  - Department of Cardiology, Koc University, Istanbul, Turkey.
FAU - Atici, Adem
AU  - Atici A
AD  - Goztepe Research and Training Hospital, Istanbul, Turkey.
FAU - Ongen, Zeki
AU  - Ongen Z
AD  - Department of Cardiology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Kocamustafapasa Street, Cerrahpasa/Fatih, 34098, Istanbul, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210223
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Echocardiography
MH  - Humans
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Predictive Value of Tests
MH  - *ST Elevation Myocardial Infarction/diagnostic imaging/therapy
MH  - Stroke Volume
MH  - *Ventricular Dysfunction, Left
MH  - Ventricular Function, Left
MH  - Ventricular Pressure
OTO - NOTNLM
OT  - Acute STEMI
OT  - Diastolic dysfunction
OT  - Invasive haemodynamic assessment
EDAT- 2021/02/25 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/02/24 05:47
PHST- 2020/08/13 00:00 [received]
PHST- 2020/12/14 00:00 [accepted]
PHST- 2021/02/25 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/02/24 05:47 [entrez]
AID - 10.1007/s10554-020-02138-3 [pii]
AID - 10.1007/s10554-020-02138-3 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2021 May;37(5):1587-1594. doi: 
      10.1007/s10554-020-02138-3. Epub 2021 Feb 23.