PMID- 33624330
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20220210
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 24
IP  - 5
DP  - 2021 Jul
TI  - Effect of Anodic Transcranial Direct Current Stimulation Combined With Speech 
      Language Therapy on Nonfluent Poststroke Aphasia.
PG  - 923-929
LID - 10.1111/ner.13337 [doi]
AB  - OBJECTIVES: Transcranial direct current stimulation (tDCS) facilitates or 
      inhibits spontaneous neuronal activity by low-intensity current. In this study, 
      we evaluated the effects of tDCS and sham stimulation combined with speech 
      language therapy (SLT) on nonfluent poststroke aphasia (PSA) patients. MATERIALS 
      AND METHODS: Patients with PSA were randomly divided into the anode tDCS (A-tDCS) 
      group (n = 8) and sham tDCS (S-tDCS) group (n = 10). The anodes and cathodes were 
      fixed over left inferior gyrus frontalis (L-IFG) and the deltoid muscle of the 
      right shoulder. A-tDCS consisted of 2 mA for 20 min, while S-tDCS current started 
      at 2 mA but automatically decreased to 0 mA after 30 sec. Stimulation was 
      concurrent with 30 min of SLT. Stimulation + SLT sessions occurred five times a 
      week for four weeks. The Western Aphasia Battery (WAB) was given before treatment 
      to obtain the baseline score and once more after all sessions were completed, and 
      the Aphasia Quotient (AQ) was calculated. RESULTS: After tDCS treatment, the AQ 
      mean(SD) in both groups was significantly higher than before treatment 
      (p < 0.001) and the AQ of the A-tDCS group 72.99 (21.91) was significantly higher 
      than that of the S-tDCS group 46.18 (19.29) (t = 2.760, p < 0.05). Upon further 
      analysis of the WAB subscores, except for comprehension, all other items were 
      significantly higher in the A-tDCS group than in the S-tDCS group (p < 0.05). 
      CONCLUSION: Our results suggest that left inferior gyrus frontalis anodic 
      transcranial direct current stimulation is an effective adjuvant to conventional 
      speech language therapy for patients with nonfluent PSA.
CI  - (c) 2021 International Neuromodulation Society.
FAU - Zhao, Qi
AU  - Zhao Q
AD  - Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of 
      Science and Technology, Collaborative Innovation Center for Brain Disorders, 
      Capital Medical University, Beijing, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Neurobiology, School of Basic Medical Sciences, Capital Medical 
      University, Beijing, China.
FAU - Li, Zheng
AU  - Li Z
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, China.
AD  - Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive 
      Neuroscience and Learning, Beijing Normal University Zhuhai, Zhuhai, China.
FAU - Song, Luping
AU  - Song L
AD  - Department of Rehabilitation Medicine, Shenzhen University General Hospital, 
      Shenzhen, China.
FAU - Li, Xiaoli
AU  - Li X
AUID- ORCID: 0000-0003-1359-5130
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, China.
AD  - Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive 
      Neuroscience and Learning, Beijing Normal University Zhuhai, Zhuhai, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210224
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
SB  - IM
MH  - *Aphasia/etiology/therapy
MH  - Double-Blind Method
MH  - Electrodes
MH  - Humans
MH  - Language Therapy
MH  - Speech
MH  - *Stroke/complications
MH  - *Transcranial Direct Current Stimulation
OTO - NOTNLM
OT  - Poststroke aphasia
OT  - rehabilitation
OT  - speech language therapy
OT  - transcranial direct current stimulation
EDAT- 2021/02/25 06:00
MHDA- 2021/08/19 06:00
CRDT- 2021/02/24 05:48
PHST- 2020/11/01 00:00 [revised]
PHST- 2020/04/29 00:00 [received]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2021/02/25 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2021/02/24 05:48 [entrez]
AID - S1094-7159(21)06201-2 [pii]
AID - 10.1111/ner.13337 [doi]
PST - ppublish
SO  - Neuromodulation. 2021 Jul;24(5):923-929. doi: 10.1111/ner.13337. Epub 2021 Feb 
      24.