PMID- 33625683
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20220125
IS  - 1559-0755 (Electronic)
IS  - 0257-277X (Linking)
VI  - 69
IP  - 2
DP  - 2021 Apr
TI  - Dysregulation of circulating follicular helper T cells in type 2 diabetic 
      patients with diabetic retinopathy.
PG  - 153-161
LID - 10.1007/s12026-021-09182-8 [doi]
AB  - Inflammation is known to be involved in the progression of diabetic retinopathy. 
      Follicular helper T cells (Tfh) play critical roles in the differentiation of 
      long-live plasma cells and production of antibodies, whereas circulating 
      CD4(+)CXCR5(+) T cells may act as a counterpart to measure Tfh cell disorders. In 
      this study, we investigated whether Tfh could be involved in the development of 
      diabetic retinopathy (DR) by assessing circulating Tfh cells in peripheral blood. 
      Data showed that serum levels of total IgG and IgA were both significantly 
      increased in type 2 diabetes mellitus (T2DM) patients with proliferative diabetic 
      retinopathy (PDR) than with non-PDR. Also, B cell activation and differentiation 
      were both enhanced in T2DM patients with PDR. Little changes were detected in 
      levels of Th1, Th2, and Th17 cells. As indicated by elevated serum levels and 
      supernatant from cultured PBMC of IL-21, we found increased circulating Tfh cells 
      in PDR patients with dysregulated subsets. This study suggests the involvement of 
      circulating Tfh cells in DR and, in particular, the pathogenesis of PDR.
FAU - Yu, Honghua
AU  - Yu H
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
AD  - Zhongshan Ophthalmic Center, SunYat-Sen University, Guangzhou, Guangdong, China.
FAU - Liu, Baoyi
AU  - Liu B
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Wu, Guanrong
AU  - Wu G
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Du, Zijing
AU  - Du Z
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Wu, Qiaowei
AU  - Wu Q
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Zeng, Xiaomin
AU  - Zeng X
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Xiao, Yu
AU  - Xiao Y
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Fang, Ying
AU  - Fang Y
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Yuan, Ling
AU  - Yuan L
AD  - Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan, China. yuanling8061@163.com.
FAU - Ma, Suihong
AU  - Ma S
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, Guangzhou, 
      China. mshwork@163.com.
AD  - School of Medicine, South China University of Technology, Guangzhou, China. 
      mshwork@163.com.
FAU - Li, Tao
AU  - Li T
AUID- ORCID: 0000-0002-2882-9297
AD  - Zhongshan Ophthalmic Center, SunYat-Sen University, Guangzhou, Guangdong, China. 
      hxydlitao@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210224
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cytokines/blood/immunology
MH  - Diabetes Mellitus, Type 2/blood/*immunology
MH  - Diabetic Retinopathy/blood/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Middle Aged
MH  - T Follicular Helper Cells/*immunology
OTO - NOTNLM
OT  - Antibody response
OT  - Circulating Tfh
OT  - PDR
OT  - T2DM
EDAT- 2021/02/25 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/02/24 12:14
PHST- 2020/10/12 00:00 [received]
PHST- 2021/02/14 00:00 [accepted]
PHST- 2021/02/25 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/02/24 12:14 [entrez]
AID - 10.1007/s12026-021-09182-8 [pii]
AID - 10.1007/s12026-021-09182-8 [doi]
PST - ppublish
SO  - Immunol Res. 2021 Apr;69(2):153-161. doi: 10.1007/s12026-021-09182-8. Epub 2021 
      Feb 24.