PMID- 33627710
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211214
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 24
TI  - Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or 
      one anastomosis gastric bypass.
PG  - 4421
LID - 10.1038/s41598-021-83807-8 [doi]
LID - 4421
AB  - This study aims to compare sleeve gastrectomy (SG) and one anastomosis gastric 
      bypass (OAGB) in terms of remission of type 2 diabetes mellitus (T2DM) in obese 
      patients. All T2DM patients were followed-up for at least 36 months. The primary 
      outcome was remission of T2DM. Secondary endpoints included weight reduction and 
      the procedure's impact on quality of life. In total, 53/1177 morbidly obese 
      patients who underwent SG (Group A, n = 28) or OAGB (Group B, n = 25) had T2DM. 
      Preoperatively, the mean Body Mass Index (BMI) values were 52.2 +/- 8.5 kg/m(2) and 
      52.9 +/- 10.9 kg/m(2) for Group A and Group B, respectively. Six patients in Group 
      A were insulin dependent, while 8 were insulin dependent in Group B. After 
      36 months, diabetes remission was achieved by only 10 patients (35.7%) in Group 
      A. However, in Group B, 22 patients (88%) remained off antidiabetic agents 
      (p < 0.0001), with DeltaHbA1c (%) reaching 1.4 +/- 1.5% in Group A and 2.7 +/- 2.1% in 
      Group B (p = 0.02). Excess weight loss% (%EWL) was again significantly different 
      between the two groups (MA = 79.8 +/- 14.5%, MB = 93.3 +/- 16.0%, p = 0.003). OAGB is 
      more effective in improving glycaemic control and %EWL, with almost immediate 
      resolution of diabetes, as well as long-term weight loss.
FAU - Vrakopoulou, Gavriella Zoi
AU  - Vrakopoulou GZ
AD  - 1St Propaedeutic Surgical Clinic, Laparoendoscopic Unit, Hippocratio Athens 
      General Hospital, Athens Medical School, National and Kapodistrian University of 
      Athens, 114 Vassilissis Sophias Avenue, 115 27, Athens, Greece. 
      g.z.vrakopoulou@gmail.com.
FAU - Theodoropoulos, Charalampos
AU  - Theodoropoulos C
AD  - 1St Propaedeutic Surgical Clinic, Laparoendoscopic Unit, Hippocratio Athens 
      General Hospital, Athens Medical School, National and Kapodistrian University of 
      Athens, 114 Vassilissis Sophias Avenue, 115 27, Athens, Greece.
FAU - Kalles, Vasileios
AU  - Kalles V
AD  - 1St Propaedeutic Surgical Clinic, Laparoendoscopic Unit, Hippocratio Athens 
      General Hospital, Athens Medical School, National and Kapodistrian University of 
      Athens, 114 Vassilissis Sophias Avenue, 115 27, Athens, Greece.
FAU - Zografos, George
AU  - Zografos G
AD  - 1St Propaedeutic Surgical Clinic, Laparoendoscopic Unit, Hippocratio Athens 
      General Hospital, Athens Medical School, National and Kapodistrian University of 
      Athens, 114 Vassilissis Sophias Avenue, 115 27, Athens, Greece.
FAU - Almpanopoulos, Konstantinos
AU  - Almpanopoulos K
AD  - 1St Propaedeutic Surgical Clinic, Laparoendoscopic Unit, Hippocratio Athens 
      General Hospital, Athens Medical School, National and Kapodistrian University of 
      Athens, 114 Vassilissis Sophias Avenue, 115 27, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20210224
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*physiopathology/*surgery
MH  - Female
MH  - Gastrectomy/methods
MH  - Gastric Bypass/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*physiopathology/*surgery
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Weight Loss/physiology
MH  - Young Adult
PMC - PMC7904834
COIS- The authors declare no competing interests.
EDAT- 2021/02/26 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/02/24
CRDT- 2021/02/25 05:39
PHST- 2020/09/02 00:00 [received]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/02/25 05:39 [entrez]
PHST- 2021/02/26 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/02/24 00:00 [pmc-release]
AID - 10.1038/s41598-021-83807-8 [pii]
AID - 83807 [pii]
AID - 10.1038/s41598-021-83807-8 [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 24;11(1):4421. doi: 10.1038/s41598-021-83807-8.