PMID- 33627770
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20240331
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 24
TI  - Physical characterization of biphasic bioceramic materials with different 
      granulation sizes and their influence on bone repair and inflammation in rat 
      calvaria.
PG  - 4484
LID - 10.1038/s41598-021-84033-y [doi]
LID - 4484
AB  - Biphasic calcium phosphate bioceramics (BCP) consist of a mixture of 
      hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) within the same 
      particle. Due to their osteoconductive properties, biocompatibility and 
      resemblance to natural bone, these materials have become a promising and suitable 
      alternative to autologous bone grafting. First, the topography characteristics, 
      specific surface area, and total pore volume of BCP were evaluated using scanning 
      electron microscopy and the BET and BJH methods. Next, this study aimed to 
      evaluate the intensity of the inflammatory process and the bone neoformation 
      capacity of various particle sizes of BCP in the repair of critical defects in 
      the calvaria of rats. A xenogeneic biomaterial was used in the control group. 
      After 30, 60, and 90 days, the animals were euthanized, followed by the 
      processing of the samples to measure the intensity of inflammatory infiltrates 
      and the areas of bone neoformation. Our results indicate that no considerable 
      differences were observed in the inflammatory scores in sites treated with 
      distinct BCP grain sizes. A greater area of bone neoformation was measured in the 
      xenogeneic group at all analysis times, with no substantial differences in bone 
      formation between the BCP particle size in the range of 250-500 microm and 
      500-1000 microm.
FAU - de Oliveira Junior, Joviniano Martins
AU  - de Oliveira Junior JM
AD  - Division of Oral Implantology, Sao Leopoldo Mandic Research Institute, Campinas, 
      SP, 13045-755, Brazil. crodf2393@gmail.com.
FAU - Montagner, Pedro Giorgetti
AU  - Montagner PG
AD  - Division of Cell Biology and Oral Pathology, Sao Leopoldo Mandic Research 
      Institute, Campinas, SP, 13045-755, Brazil.
FAU - Carrijo, Rafael Coutinho
AU  - Carrijo RC
AD  - Division of Oral Implantology, Sao Leopoldo Mandic Research Institute, Campinas, 
      SP, 13045-755, Brazil.
FAU - Martinez, Elizabeth Ferreira
AU  - Martinez EF
AD  - Division of Cell Biology and Oral Pathology, Sao Leopoldo Mandic Research 
      Institute, Campinas, SP, 13045-755, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210224
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Hydroxyapatites)
RN  - 0 (beta-tricalcium phosphate)
RN  - 0 (hydroxyapatite-beta tricalcium phosphate)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*pharmacology
MH  - Bone Regeneration/drug effects
MH  - Bone Substitutes/*pharmacology
MH  - Calcium Phosphates/pharmacology
MH  - Durapatite/pharmacology
MH  - Hydroxyapatites/*pharmacology
MH  - Inflammation/*drug therapy
MH  - Male
MH  - Microscopy, Electron, Scanning/methods
MH  - Osteogenesis/*drug effects
MH  - Porosity/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Skull/*drug effects
PMC - PMC7904940
COIS- The authors declare no competing interests.
EDAT- 2021/02/26 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/02/24
CRDT- 2021/02/25 05:40
PHST- 2020/12/09 00:00 [received]
PHST- 2021/02/10 00:00 [accepted]
PHST- 2021/02/25 05:40 [entrez]
PHST- 2021/02/26 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/02/24 00:00 [pmc-release]
AID - 10.1038/s41598-021-84033-y [pii]
AID - 84033 [pii]
AID - 10.1038/s41598-021-84033-y [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 24;11(1):4484. doi: 10.1038/s41598-021-84033-y.