PMID- 33628036
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 1178-6965 (Print)
IS  - 1178-6965 (Electronic)
IS  - 1178-6965 (Linking)
VI  - 14
DP  - 2021
TI  - The Role of Phadiatop Tests and Total Immunoglobulin E Levels in Screening 
      Aeroallergens: A Hospital-Based Cohort Study.
PG  - 135-140
LID - 10.2147/JAA.S292710 [doi]
AB  - BACKGROUND: Screening for the existence of aeroallergens in patients with 
      possible allergic rhinitis using venous blood samples has become more popular, 
      with advantages of increased convenience and less consumption of time. OBJECTIVE: 
      The aim of this study was to investigate the sensitivities and specificities of 
      Phadiatop tests and total immunoglobulin E (IgE) levels in both adults and 
      children. METHODS: This study was conducted prospectively in a tertiary center. 
      The process of recruitment took place from Jan 2015 to Dec 2019, and patients 
      with clinical symptoms that suggested persistent allergic rhinitis were recruited 
      and their serum samples collected. The results of the total IgE and Phadiatop 
      tests as well as the positive items in the ImmunoCAP assay were recorded and 
      analyzed. RESULTS: A total of 9174 cases with complete data were enrolled, 
      including 576 children and 8598 adults. A positive result in the ImmunoCAP assay 
      was considered a positive atopic status towards aeroallergens. While using the 
      total IgE levels to predict positive aeroallergens, the sensitivities and 
      specificities were 65.7% and 85.7%, respectively, for adults and 86.3% and 77.4%, 
      respectively, for children. When we used Phadiatop tests for allergy screening, 
      the sensitivities and specificities was 94.5% and 98.2%, respectively, for the 
      adult group and 98.5% and 96.8%, respectively, for the pediatric group. 
      CONCLUSION: The Phadiatop test had better diagnostic power for aeroallergen 
      detection than the serum total IgE levels, or even the dual test, for both the 
      adult and pediatric groups in this hospital-based study. We suggest that the 
      Phadiatop test is more cost-effective in aeroallergen screening for patients with 
      suspected atopic airway diseases.
CI  - (c) 2021 Chang et al.
FAU - Chang, Yun-Chen
AU  - Chang YC
AD  - Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial 
      Hospital, Taoyuan City, 333, Taiwan.
FAU - Lee, Ta-Jen
AU  - Lee TJ
AD  - Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial 
      Hospital, Taoyuan City, 333, Taiwan.
FAU - Huang, Chi-Che
AU  - Huang CC
AD  - Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial 
      Hospital, Taoyuan City, 333, Taiwan.
AD  - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung 
      University, Taoyuan City, 333, Taiwan.
FAU - Chang, Po-Hung
AU  - Chang PH
AD  - Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial 
      Hospital, Taoyuan City, 333, Taiwan.
AD  - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung 
      University, Taoyuan City, 333, Taiwan.
FAU - Chen, Yi-Wei
AU  - Chen YW
AD  - Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial 
      Hospital, Taoyuan City, 333, Taiwan.
FAU - Fu, Chia-Hsiang
AU  - Fu CH
AD  - Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial 
      Hospital, Taoyuan City, 333, Taiwan.
AD  - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung 
      University, Taoyuan City, 333, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20210217
PL  - New Zealand
TA  - J Asthma Allergy
JT  - Journal of asthma and allergy
JID - 101543450
PMC - PMC7898199
OTO - NOTNLM
OT  - IgE
OT  - ImmunoCAP
OT  - Phadiatop test
OT  - aeroallergens
OT  - total immunoglobulin E
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/02/26 06:00
MHDA- 2021/02/26 06:01
PMCR- 2021/02/17
CRDT- 2021/02/25 05:43
PHST- 2020/12/07 00:00 [received]
PHST- 2021/01/28 00:00 [accepted]
PHST- 2021/02/25 05:43 [entrez]
PHST- 2021/02/26 06:00 [pubmed]
PHST- 2021/02/26 06:01 [medline]
PHST- 2021/02/17 00:00 [pmc-release]
AID - 292710 [pii]
AID - 10.2147/JAA.S292710 [doi]
PST - epublish
SO  - J Asthma Allergy. 2021 Feb 17;14:135-140. doi: 10.2147/JAA.S292710. eCollection 
      2021.