PMID- 33628521
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210226
IS  - 2090-6404 (Print)
IS  - 2090-6412 (Electronic)
IS  - 2090-6404 (Linking)
VI  - 2021
DP  - 2021
TI  - Sibutramine as a Cause of Sudden Cardiac Death.
PG  - 8896932
LID - 10.1155/2021/8896932 [doi]
LID - 8896932
AB  - Importance. Sibutramine was withdrawn from the US market due to association with 
      adverse cardiovascular outcomes especially with patients having preexisting 
      cardiac disease. However, continued presence of sibutramine in herbal medications 
      is a concern to public safety. Results. We report a case of a patient with no 
      evidence of previous coronary heart disease, who presented with non-ST elevation 
      acute coronary syndrome (NSTE-ACS). Urgent coronary catheterization showed 
      nonobstructive coronaries. However, patient died unexpectedly within 24 hours of 
      admission. The patient denied toxic habits but was taking over-the-counter weight 
      loss herbal supplements. Complete autopsy was performed which showed sibutramine 
      in the toxicology. Patient died due to complications of acute inadvertent 
      intoxication of sibutramine. Conclusion and Relevance. This is the first case 
      report in literature showing association of sibutramine to sudden cardiac death 
      in patients with no prior cardiac history. The continued presence of sibutramine 
      in some over-the-counter weight loss formulations is a very concerning public 
      health issue.
CI  - Copyright (c) 2021 Miguel Rodriguez-Guerra et al.
FAU - Rodriguez-Guerra, Miguel
AU  - Rodriguez-Guerra M
AUID- ORCID: 0000-0002-7047-6077
AD  - BronxCare Health System, New York, USA.
FAU - Yadav, Mayank
AU  - Yadav M
AD  - BronxCare Health System, New York, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, USA.
FAU - Bhandari, Manoj
AU  - Bhandari M
AD  - BronxCare Health System, New York, USA.
FAU - Sinha, Archna
AU  - Sinha A
AD  - St. Charles Hospital, Port Jefferson, New York, USA.
FAU - Bella, Jonathan N
AU  - Bella JN
AD  - BronxCare Health System, New York, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, USA.
FAU - Sklyar, Eduard
AU  - Sklyar E
AD  - BronxCare Health System, New York, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, USA.
LA  - eng
PT  - Case Reports
DEP - 20210206
PL  - United States
TA  - Case Rep Cardiol
JT  - Case reports in cardiology
JID - 101576452
PMC - PMC7884177
COIS- None of the authors report any conflicts of interest.
EDAT- 2021/02/26 06:00
MHDA- 2021/02/26 06:01
PMCR- 2021/02/06
CRDT- 2021/02/25 05:45
PHST- 2020/05/06 00:00 [received]
PHST- 2021/01/03 00:00 [revised]
PHST- 2021/01/28 00:00 [accepted]
PHST- 2021/02/25 05:45 [entrez]
PHST- 2021/02/26 06:00 [pubmed]
PHST- 2021/02/26 06:01 [medline]
PHST- 2021/02/06 00:00 [pmc-release]
AID - 10.1155/2021/8896932 [doi]
PST - epublish
SO  - Case Rep Cardiol. 2021 Feb 6;2021:8896932. doi: 10.1155/2021/8896932. eCollection 
      2021.