PMID- 33628540
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210324
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2021
DP  - 2021
TI  - Severe Aplastic Anemia as First Manifestation of Classical Hodgkin Lymphoma.
PG  - 8876249
LID - 10.1155/2021/8876249 [doi]
LID - 8876249
AB  - Autoimmune cytopenia, a known paraneoplastic complication of lymphoid neoplasms, 
      may occur before, concurrently, at relapse, or even years after completion of 
      lymphoma treatment. In the case of Hodgkin lymphoma (HL), it is thought that 
      immune dysregulation, typical of this neoplasm, may be involved in the genesis of 
      these manifestations. We report a 57-year-old male presenting with stage IIIA, 
      International Prognostic Score (IPS) 4, nodular sclerosis HL, and severe AA (SAA) 
      confirmed on the histologic exam of the bone marrow that showed severe marrow 
      hypoplasia due to a decrease in the elements of the three cell linages with left 
      shift of the myeloid maturation. Immunosuppression with steroids and cyclosporine 
      A was started. Eltrombopag and G-CSF were also added. In spite of prompt 
      initiation of immunosuppressive therapy, the patient presented an unfavorable 
      outcome with progressive pancytopenia and severe acute cerebral hemorrhagic 
      event. The patient died 59 days after admission. Although autoimmune disorders 
      are described in HL, its concomitant diagnosis is extremely rare. Our case shows 
      a rare instance of SAA as the first manifestation of HL.
CI  - Copyright (c) 2021 Claudia L. Pedrosa et al.
FAU - Pedrosa, Claudia L
AU  - Pedrosa CL
AUID- ORCID: 0000-0001-6566-0315
AD  - Department of Clinical Hematology, Centro Hospitalar Universitario Do Porto, 
      Porto, Portugal.
FAU - Rosinha, Patricia
AU  - Rosinha P
AD  - Department of Internal Medicine, Centro Hospitalar Do Baixo Vouga, Aveiro, 
      Portugal.
FAU - Seabra, Patricia
AU  - Seabra P
AD  - Department of Clinical Hematology, Centro Hospitalar Universitario Do Porto, 
      Porto, Portugal.
FAU - Ferreira, Gisela
AU  - Ferreira G
AD  - Department of Clinical Hematology, Centro Hospitalar Do Baixo Vouga, Aveiro, 
      Portugal.
FAU - Rosado, Claudia
AU  - Rosado C
AD  - Department of Internal Medicine, Centro Hospitalar Do Baixo Vouga, Aveiro, 
      Portugal.
FAU - Regadas, Luisa
AU  - Regadas L
AD  - Department of Clinical Hematology, Centro Hospitalar Universitario Do Porto, 
      Porto, Portugal.
FAU - Casais, Claudia
AU  - Casais C
AD  - Department of Clinical Hematology, Centro Hospitalar Universitario Do Porto, 
      Porto, Portugal.
FAU - Coutinho, Jorge
AU  - Coutinho J
AD  - Department of Clinical Hematology, Centro Hospitalar Universitario Do Porto, 
      Porto, Portugal.
LA  - eng
PT  - Case Reports
DEP - 20210209
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC7886563
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/02/26 06:00
MHDA- 2021/02/26 06:01
PMCR- 2021/02/09
CRDT- 2021/02/25 05:46
PHST- 2020/08/24 00:00 [received]
PHST- 2021/01/20 00:00 [revised]
PHST- 2021/01/27 00:00 [accepted]
PHST- 2021/02/25 05:46 [entrez]
PHST- 2021/02/26 06:00 [pubmed]
PHST- 2021/02/26 06:01 [medline]
PHST- 2021/02/09 00:00 [pmc-release]
AID - 10.1155/2021/8876249 [doi]
PST - epublish
SO  - Case Rep Hematol. 2021 Feb 9;2021:8876249. doi: 10.1155/2021/8876249. eCollection 
      2021.