PMID- 33629608
OWN - NLM
STAT- MEDLINE
DCOM- 20210830
LR  - 20220426
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Print)
IS  - 0003-4894 (Linking)
VI  - 130
IP  - 10
DP  - 2021 Oct
TI  - Association of Social Determinants of Health with Time to Diagnosis and Treatment 
      Outcomes in Idiopathic Subglottic Stenosis.
PG  - 1116-1124
LID - 10.1177/0003489421995283 [doi]
AB  - OBJECTIVES: To examine whether social determinants of health (SDH) factors are 
      associated with time to diagnosis, treatment selection, and time to recurrent 
      surgical intervention in idiopathic subglottic stenosis (iSGS) patients. METHODS: 
      Adult patients with diagnosed iSGS were recruited prospectively (2015-2017) via 
      clinical providers as part of the North American Airway Collaborative (NoAAC) and 
      via an online iSGS support community on Facebook. Patient-specific SDH factors 
      included highest educational attainment (self-reported), median household income 
      (matched from home zip code via U.S. Census data), and number of close friends 
      (self-reported) as a measure of social support. Main outcomes of interest were 
      time to disease diagnosis (years from symptom onset), treatment selection 
      (endoscopic dilation [ED] vs cricotracheal resection [CTR] vs endoscopic 
      resection with adjuvant medical therapy [ERMT]), and time to recurrent surgical 
      intervention (number of days from initial surgical procedure) as a surrogate for 
      disease recurrence. RESULTS: The total 810 participants were 98.5% female, 97.2% 
      Caucasian, and had a median age of 50 years (IQR, 43-58). The cohort had a median 
      household income of $62 307 (IQR, $50 345-$79 773), a median of 7 close friends 
      (IQR, 4-10), and 64.7% of patients completed college or graduate school. 
      Education, income, and number of friends were not associated with time to 
      diagnosis via multivariable linear regression modeling. Univariable multinominal 
      logistic regression demonstrated an association between education and income for 
      selecting ED versus ERMT, but no associations were noted for CTR. No associations 
      were noted for time to recurrent surgical procedure via Kaplan Meier modeling and 
      Cox proportional hazards regression. CONCLUSIONS: Patient education, income, and 
      social support were not associated with time to diagnosis or time to disease 
      recurrence. This suggests additional patient, procedure, or disease-specific 
      factors contribute to the observed variations in iSGS surgical outcomes.
FAU - Lee, Jaclyn
AU  - Lee J
AUID- ORCID: 0000-0001-9804-6995
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Huang, Li-Ching
AU  - Huang LC
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Berry, Lynn D
AU  - Berry LD
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Anderson, Catherine
AU  - Anderson C
AD  - Australian Market and Social Research Society, Glebe, NSW, Australia.
FAU - Amin, Milan R
AU  - Amin MR
AD  - NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York 
      University School of Medicine, New York, NY, USA.
FAU - Benninger, Michael S
AU  - Benninger MS
AD  - Department of Otolaryngology-Head and Neck Surgery, Head and Neck Institute, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Blumin, Joel H
AU  - Blumin JH
AD  - Division of Laryngology and Professional Voice, Department of Otolaryngology and 
      Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
FAU - Bock, Jonathan M
AU  - Bock JM
AUID- ORCID: 0000-0002-4367-7527
AD  - Division of Laryngology and Professional Voice, Department of Otolaryngology and 
      Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
FAU - Bryson, Paul C
AU  - Bryson PC
AD  - Department of Otolaryngology-Head and Neck Surgery, Head and Neck Institute, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Castellanos, Paul F
AU  - Castellanos PF
AD  - Division of Otolaryngology, Department of Surgery, University of Alabama at 
      Birmingham, Birmingham, AL, USA.
FAU - Chen, Sheau-Chiann
AU  - Chen SC
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Clary, Matthew S
AU  - Clary MS
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Colorado School 
      of Medicine, Denver, CO, USA.
FAU - Cohen, Seth M
AU  - Cohen SM
AUID- ORCID: 0000-0002-7965-604X
AD  - Duke Voice Care Center, Division of Otolaryngology-Head and Neck Surgery, Duke 
      University Medical Center, Durham, NC, USA.
FAU - Crawley, Brianna K
AU  - Crawley BK
AD  - Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Health, 
      Loma Linda, CA, USA.
FAU - Dailey, Seth H
AU  - Dailey SH
AUID- ORCID: 0000-0002-3299-3014
AD  - Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Health, 
      Loma Linda, CA, USA.
FAU - Daniero, James J
AU  - Daniero JJ
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health 
      System, Charlottesville, VA, USA.
FAU - de Alarcon, Alessandro
AU  - de Alarcon A
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, 
      Cincinnati, OH, USA.
FAU - Donovan, Donald T
AU  - Donovan DT
AD  - Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, 
      Houston, TX, USA.
FAU - Edell, Eric S
AU  - Edell ES
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 
      USA.
FAU - Ekbom, Dale C
AU  - Ekbom DC
AD  - Department of Otolaryngology, Mayo Clinic College of Medicine and Science, 
      Rochester, MN, USA.
FAU - Fink, Daniel S
AU  - Fink DS
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Colorado School 
      of Medicine, Denver, CO, USA.
FAU - Franco, Ramon A
AU  - Franco RA
AD  - Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear 
      Infirmary, Boston, MA, USA.
FAU - Garrett, C Gaelyn
AU  - Garrett CG
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Guardiani, Elizabeth A
AU  - Guardiani EA
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland 
      School of Medicine, Baltimore, MD, USA.
FAU - Hillel, Alexander T
AU  - Hillel AT
AD  - Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical 
      Institution, Baltimore, MD, USA.
FAU - Hoffman, Henry T
AU  - Hoffman HT
AUID- ORCID: 0000-0003-4486-855X
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals 
      and Clinics, Iowa City, IA, USA.
FAU - Hogikyan, Norman D
AU  - Hogikyan ND
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Michigan 
      Medical Center, Ann Arbor, MI, USA.
FAU - Howell, Rebecca J
AU  - Howell RJ
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, 
      Cincinnati, OH, USA.
FAU - Hussain, Lena K
AU  - Hussain LK
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Johns, Michael M
AU  - Johns MM
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Southern 
      California, Los Angeles, CA, USA.
FAU - Kasperbauer, Jan L
AU  - Kasperbauer JL
AD  - Department of Otolaryngology, Mayo Clinic College of Medicine and Science, 
      Rochester, MN, USA.
FAU - Khosla, Sid M
AU  - Khosla SM
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, 
      Cincinnati, OH, USA.
FAU - Kinnard, Cheryl
AU  - Kinnard C
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Kupfer, Robbi A
AU  - Kupfer RA
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Michigan 
      Medical Center, Ann Arbor, MI, USA.
FAU - Langerman, Alexander J
AU  - Langerman AJ
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Lentz, Robert J
AU  - Lentz RJ
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Lorenz, Robert R
AU  - Lorenz RR
AD  - Division of Laryngology and Professional Voice, Department of Otolaryngology and 
      Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
FAU - Lott, David G
AU  - Lott DG
AUID- ORCID: 0000-0001-6541-9687
AD  - Department of Otorhinolaryngology, Mayo Clinic Scottsdale, Scottsdale, AZ, USA.
FAU - Lowery, Anne S
AU  - Lowery AS
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Makani, Samir S
AU  - Makani SS
AD  - Division of Pulmonary and Critical Care Medicine, University of California, San 
      Diego, San Diego, CA, USA.
FAU - Maldonado, Fabien
AU  - Maldonado F
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Mannion, Kyle
AU  - Mannion K
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Matrka, Laura
AU  - Matrka L
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Medical Center, Columbus, OH, USA.
FAU - McWhorter, Andrew J
AU  - McWhorter AJ
AD  - Department of Otolaryngology, Louisiana State University Health Sciences 
      Center-New Orleans, New Orleans, LA, USA.
FAU - Merati, Albert L
AU  - Merati AL
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Washington 
      Medical Center, Seattle, WA, USA.
FAU - Mori, Matthew
AU  - Mori M
AUID- ORCID: 0000-0001-8743-5055
AD  - Department of Otolaryngology, New York Eye and Ear Infirmary of Mount Sinai, New 
      York, NY USA.
FAU - Netterville, James L
AU  - Netterville JL
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - O'Dell, Karla
AU  - O'Dell K
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Southern 
      California, Los Angeles, CA, USA.
FAU - Ongkasuwan, Julina
AU  - Ongkasuwan J
AUID- ORCID: 0000-0001-8621-5456
AD  - Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, 
      Houston, TX, USA.
FAU - Postma, Gregory N
AU  - Postma GN
AD  - Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia at 
      Augusta University, Augusta, GA, USA.
FAU - Reder, Lindsay S
AU  - Reder LS
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Southern 
      California, Los Angeles, CA, USA.
FAU - Rohde, Sarah L
AU  - Rohde SL
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Richardson, Brent E
AU  - Richardson BE
AUID- ORCID: 0000-0001-5332-1930
AD  - Bastian Voice Institute, Downers Grove, IL, USA.
FAU - Rickman, Otis B
AU  - Rickman OB
AD  - Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University 
      Medical Center, Nashville, TN, USA.
FAU - Rosen, Clark A
AU  - Rosen CA
AD  - Department of Otolaryngology-Head and Neck Surgery, University of California, San 
      Francisco, San Francisco, CA, USA.
FAU - Rutter, Michael J
AU  - Rutter MJ
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, 
      Cincinnati, OH, USA.
FAU - Sandhu, Guri S
AU  - Sandhu GS
AD  - National Centre for Airway Reconstruction, Charing Cross Hospital, Imperial 
      College Healthcare NHS Trust, London, UK.
FAU - Schindler, Joshua S
AU  - Schindler JS
AD  - Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science 
      University, Northwest Clinic for Voice and Swallowing, Portland, OR, USA.
FAU - Schneider, G Todd
AU  - Schneider GT
AD  - Department of Otolaryngology, University of Rochester, Rochester, NY, USA.
FAU - Shah, Rupali N
AU  - Shah RN
AD  - Department of Otolaryngology-Head and Neck Surgery, University of North Carolina 
      at Chapel Hill, Chapel Hill, NC, USA.
FAU - Sikora, Andrew G
AU  - Sikora AG
AD  - Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, 
      Houston, TX, USA.
FAU - Sinard, Robert J
AU  - Sinard RJ
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Smith, Marshall E
AU  - Smith ME
AD  - Division of Otolaryngology-Head and Neck Surgery, The University of Utah, Salt 
      Lake City, UT, USA.
FAU - Smith, Libby J
AU  - Smith LJ
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, 
      Pittsburgh, PA, USA.
FAU - Soliman, Ahmed M S
AU  - Soliman AMS
AD  - Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine 
      at Temple University, Philadelphia, PA, USA.
FAU - Sveinsdottir, Sigriethur
AU  - Sveinsdottir S
AD  - Landspitali University Hospital, Reykjavik, Iceland.
FAU - Van Daele, Douglas J
AU  - Van Daele DJ
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals 
      and Clinics, Iowa City, IA, USA.
FAU - Veivers, David
AU  - Veivers D
AD  - Department of Otolaryngology-Head and Neck Surgery, Royal North Shore Hospital, 
      Sydney, NSW, Australia.
FAU - Verma, Sunil P
AU  - Verma SP
AD  - Department of Otolaryngology-Head and Neck Surgery, University of California, 
      Irvine, CA, USA.
FAU - Weinberger, Paul M
AU  - Weinberger PM
AD  - Departments of Otolaryngology, Molecular and Cellular Physiology, Feist-Weiller 
      Cancer Center, LSU Shreveport, LA, USA.
FAU - Weissbrod, Philip A
AU  - Weissbrod PA
AD  - Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, 
      University of California, San Diego, San Diego, CA, USA.
FAU - Wootten, Christopher T
AU  - Wootten CT
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
FAU - Shyr, Yu
AU  - Shyr Y
AD  - Vanderbilt Center for Quantitative Sciences, Vanderbilt-Ingram Cancer Center, 
      Nashville, TN, USA.
FAU - Francis, David O
AU  - Francis DO
AD  - Division of Otolaryngology-Head and Neck Surgery, University of 
      Wisconsin-Madison, Madison, WI, USA.
FAU - Gelbard, Alexander
AU  - Gelbard A
AUID- ORCID: 0000-0003-0078-1305
AD  - Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical 
      Center, Nashville, TN, USA.
LA  - eng
GR  - R01 HL146401/HL/NHLBI NIH HHS/United States
GR  - R21 DC016724/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20210225
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
SB  - IM
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngoscopy/*methods
MH  - Laryngostenosis/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Recurrence
MH  - *Social Determinants of Health
MH  - Time Factors
MH  - Treatment Outcome
MH  - United States
PMC - PMC8762607
MID - NIHMS1768349
OTO - NOTNLM
OT  - education
OT  - iSGS
OT  - income
OT  - social support
OT  - surgical outcomes
OT  - time to diagnosis
COIS- Conflicts of Interest Disclosures: None.
EDAT- 2021/02/26 06:00
MHDA- 2021/08/31 06:00
PMCR- 2022/01/17
CRDT- 2021/02/25 08:38
PHST- 2021/02/26 06:00 [pubmed]
PHST- 2021/08/31 06:00 [medline]
PHST- 2021/02/25 08:38 [entrez]
PHST- 2022/01/17 00:00 [pmc-release]
AID - 10.1177/0003489421995283 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2021 Oct;130(10):1116-1124. doi: 
      10.1177/0003489421995283. Epub 2021 Feb 25.