PMID- 33631947
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20220531
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 35
IP  - 6
DP  - 2021 Nov
TI  - Measurement of Tryptase and CC16/Albumin in Nasal Lavage Fluid as a Screening 
      Tool of Allergic Rhinitis.
PG  - 768-773
LID - 10.1177/1945892421998260 [doi]
AB  - BACKGROUND: There is no trial to make a diagnostic tool of allergic rhinitis (AR) 
      utilizing biomarkers from nasal fluid. Base on previous studies, we selected 
      following five biomarkers in nasal fluids that represent the characteristics of 
      allergic reactions: tryptase, eosinophil cationic protein (ECP), interleukin 5 
      (IL-5), Clara cell protein 16 (CC16) and CC16-to-albumin ratio. OBJECTIVE: This 
      study aimed to identify biomarkers in nasal discharge that may be used in 
      biosensors to diagnose AR as an additional diagnostic tool. METHODS: Patients 
      showed rhinorrhea and tested positive on allergic skin and specific 
      immunoglobulin E (IgE) tests were included in the AR group. The non-AR group 
      included individuals no dominant nasal symptoms and tested negative on allergy 
      tests. Nasal lavage fluid samples were collected from all participants. 
      Biomarkers in the samples were quantified using enzyme-linked immunosorbent 
      assay. RESULTS: Forty-five patients with AR and 28 non-AR subjects were enrolled 
      in this study. Comparing the concentrations of biomarkers, the concentrations of 
      tryptase and IL-5 were significantly higher in the AR group than in the NAR 
      group. And CC16 level and CC16-to-albumin ratio were significantly lower in the 
      AR group. In the combination of tryptase or CC16-to-albumin ratio, the 
      sensitivity was 90.7% and the specificity was 64.3% (p = 0.013). CONCLUSION: The 
      combination of "tryptase or CC16-to-albumin" could be used as a screening tool 
      for AR. Although this diagnostic method could not replace conventional diagnostic 
      tools, we could consider the method we proposed as an additional screening tool 
      for patients who could not undergo allergy tests.
FAU - Kwon, Oh Eun
AU  - Kwon OE
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Lee, Young Chan
AU  - Lee YC
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Park, Jung Min
AU  - Park JM
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Kim, Sung Wan
AU  - Kim SW
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Eun, Young-Gyu
AU  - Eun YG
AUID- ORCID: 0000-0003-4081-5207
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Ko, Seong-Gyu
AU  - Ko SG
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210225
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Albumins)
RN  - 0 (SCGB1A1 protein, human)
RN  - 9060-09-7 (Uteroglobin)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Albumins
MH  - Humans
MH  - Nasal Lavage Fluid
MH  - Nasal Mucosa
MH  - *Rhinitis, Allergic/diagnosis
MH  - Tryptases/*analysis
MH  - Uteroglobin/*analysis
OTO - NOTNLM
OT  - Clara cell 16
OT  - allergic rhinitis
OT  - interleukin 5
OT  - screening
OT  - tryptase
EDAT- 2021/02/27 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/02/26 05:36
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/02/26 05:36 [entrez]
AID - 10.1177/1945892421998260 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2021 Nov;35(6):768-773. doi: 10.1177/1945892421998260. Epub 
      2021 Feb 25.