PMID- 33632163
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Feb 25
TI  - A rare case of multiple endocrine neoplasia type 1 initially presenting as an 
      asymptomatic, huge mediastinal mass: case report.
PG  - 31
LID - 10.1186/s12902-021-00695-9 [doi]
LID - 31
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited 
      syndrome that concurrently involves various endocrine glands. We report a rare 
      case of MEN1 in a 43-year-old man whose first manifestation was an asymptomatic 
      mediastinal mass. CASE PRESENTATION: A 13-cm-sized mediastinal mass was diagnosed 
      as an atypical thymic carcinoid by computed tomography and percutaneous needle 
      biopsy. In addition, hypercalcemia from a left inferior parathyroid hyperplasia, 
      and a non-functioning gastric neuroendocrine tumor seen on 
      esophagogastroduodenoscopy were found. Therefore, the patient was clinically 
      diagnosed with MEN1 syndrome, and underwent surgical resection of thymic 
      carcinoid tumor after pre-operative concurrent chemoradiation therapy to decrease 
      tumor size and volume. Parathyroid lesion and gastric neuroendocrine tumor were 
      also removed. Finally, a MEN1 gene mutation was observed in the patient and his 
      7-year-old son. CONCLUSION: Despite its rare occurrence, thymic carcinoid tumor 
      should be considered as a MEN1-associated tumor and necessitates screening of 
      other endocrine glands. Thymic carcinoid tumor carries a poor prognosis in 
      patients with MEN1, and thus it needs to be carefully monitored even after 
      radical excision.
FAU - Jun, Ji Eun
AU  - Jun JE
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, 
      Seoul, 05278, Republic of Korea.
FAU - Hwang, You-Cheol
AU  - Hwang YC
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, 
      Seoul, 05278, Republic of Korea.
FAU - Ahn, Kyu Jeong
AU  - Ahn KJ
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, 
      Seoul, 05278, Republic of Korea.
FAU - Chung, Ho Yeon
AU  - Chung HY
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, 
      Seoul, 05278, Republic of Korea.
FAU - Jeong, In-Kyung
AU  - Jeong IK
AUID- ORCID: 0000-0001-7857-546X
AD  - Department of Endocrinology and Metabolism, Kyung Hee University Hospital at 
      Gangdong, Kyung Hee University School of Medicine, 892 Dongnam-ro, Gangdong-gu, 
      Seoul, 05278, Republic of Korea. jik1016@naver.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210225
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Adult
MH  - *Asymptomatic Diseases
MH  - Humans
MH  - Male
MH  - Mediastinal Neoplasms/complications/*diagnostic imaging
MH  - Multiple Endocrine Neoplasia Type 1/complications/*diagnostic imaging
MH  - Thymoma/complications/*diagnostic imaging
MH  - Thymus Neoplasms/complications/*diagnostic imaging
PMC - PMC7905909
OTO - NOTNLM
OT  - Case report
OT  - MEN1
OT  - Multiple endocrine neoplasia
OT  - Thymic carcinoid tumor
COIS- The authors have no competing interest to disclose.
EDAT- 2021/02/27 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/02/25
CRDT- 2021/02/26 05:38
PHST- 2020/08/27 00:00 [received]
PHST- 2021/02/09 00:00 [accepted]
PHST- 2021/02/26 05:38 [entrez]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 10.1186/s12902-021-00695-9 [pii]
AID - 695 [pii]
AID - 10.1186/s12902-021-00695-9 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2021 Feb 25;21(1):31. doi: 10.1186/s12902-021-00695-9.