PMID- 33632295
OWN - NLM
STAT- MEDLINE
DCOM- 20210304
LR  - 20240331
IS  - 1757-2215 (Electronic)
IS  - 1757-2215 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Feb 25
TI  - Comorbidities and inflammation associated with ovarian cancer and its influence 
      on SARS-CoV-2 infection.
PG  - 39
LID - 10.1186/s13048-021-00787-z [doi]
LID - 39
AB  - Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory 
      syndrome coronavirus 2 (SARS-CoV-2) worldwide is a major public health concern. 
      Cancer patients are considered a vulnerable population to SARS-CoV-2 infection 
      and may develop several COVID-19 symptoms. The heightened immunocompromised 
      state, prolonged chronic pro-inflammatory milieu coupled with comorbid conditions 
      are shared in both disease conditions and may influence patient outcome. Although 
      ovarian cancer (OC) and COVID-19 are diseases of entirely different primary 
      organs, both diseases share similar molecular and cellular characteristics in 
      their microenvironment suggesting a potential cooperativity leading to poor 
      outcome. In COVID-19 related cases, hospitalizations and deaths worldwide are 
      lower in women than in males; however, comorbidities associated with OC may 
      increase the COVID-19 risk in women. The women at the age of 50-60 years are at 
      greater risk of developing OC as well as SARS-CoV-2 infection. Increased levels 
      of gonadotropin and androgen, dysregulated renin-angiotensin-aldosterone system 
      (RAAS), hyper-coagulation and chronic inflammation are common conditions observed 
      among OC and severe cases of COVID-19. The upregulation of common inflammatory 
      cytokines and chemokines such as tumor necrosis factor alpha (TNF-alpha), interleukin 
      (IL)-1beta, IL-2, IL-6, IL-10, interferon-gamma-inducible protein 10 (IP-10), 
      granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 
      (MCP-1), macrophage colony-stimulating factor (M-CSF), among others in the sera 
      of COVID-19 and OC subjects suggests potentially similar mechanism(s) involved in 
      the hyper-inflammatory condition observed in both disease states. Thus, it is 
      conceivable that the pathogenesis of OC may significantly contribute to the 
      potential infection by SARS-CoV-2. Our understanding of the influence and 
      mechanisms of SARS-CoV-2 infection on OC is at an early stage and in this 
      article, we review the underlying pathogenesis presented by various comorbidities 
      of OC and correlate their influence on SARS-CoV-2 infection.
FAU - Chaudhari, Sima
AU  - Chaudhari S
AD  - Department of Cell and Molecular Biology, Manipal School of Life Science, Manipal 
      Academy of Higher Education, Manipal, Karnataka, 576104, India.
FAU - Dey Pereira, Satyajit
AU  - Dey Pereira S
AD  - Department of Cell and Molecular Biology, Manipal School of Life Science, Manipal 
      Academy of Higher Education, Manipal, Karnataka, 576104, India.
FAU - Asare-Warehene, Meshach
AU  - Asare-Warehene M
AD  - Chronic Disease Program, Ottawa Hospital Research Institute and Department of 
      Obstetrics & Gynecology and Cellular and Molecular Medicine, University of 
      Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
FAU - Naha, Ritam
AU  - Naha R
AD  - Department of Cell and Molecular Biology, Manipal School of Life Science, Manipal 
      Academy of Higher Education, Manipal, Karnataka, 576104, India.
FAU - Kabekkodu, Shama Prasada
AU  - Kabekkodu SP
AD  - Department of Cell and Molecular Biology, Manipal School of Life Science, Manipal 
      Academy of Higher Education, Manipal, Karnataka, 576104, India.
FAU - Tsang, Benjamin K
AU  - Tsang BK
AD  - Chronic Disease Program, Ottawa Hospital Research Institute and Department of 
      Obstetrics & Gynecology and Cellular and Molecular Medicine, University of 
      Ottawa, Ottawa, Ontario, K1N 6N5, Canada.
FAU - Satyamoorthy, Kapaettu
AU  - Satyamoorthy K
AUID- ORCID: 0000-0002-2368-5490
AD  - Department of Cell and Molecular Biology, Manipal School of Life Science, Manipal 
      Academy of Higher Education, Manipal, Karnataka, 576104, India. 
      ksatyamoorthy@manipal.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210225
PL  - England
TA  - J Ovarian Res
JT  - Journal of ovarian research
JID - 101474849
RN  - 0 (Cytokines)
SB  - IM
MH  - COVID-19/*epidemiology/*etiology
MH  - Comorbidity
MH  - Cytokines/metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/*epidemiology/virology
MH  - Middle Aged
MH  - Ovarian Neoplasms/*epidemiology/*pathology
MH  - Renin-Angiotensin System/physiology
MH  - Tumor Microenvironment
PMC - PMC7906086
OTO - NOTNLM
OT  - Hormones
OT  - Inflammation
OT  - Ovarian cancer
OT  - SARS-CoV-2
OT  - risk factor
COIS- The authors declare that they have no competing interests
EDAT- 2021/02/27 06:00
MHDA- 2021/03/05 06:00
PMCR- 2021/02/25
CRDT- 2021/02/26 05:39
PHST- 2020/11/21 00:00 [received]
PHST- 2021/02/09 00:00 [accepted]
PHST- 2021/02/26 05:39 [entrez]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/03/05 06:00 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 10.1186/s13048-021-00787-z [pii]
AID - 787 [pii]
AID - 10.1186/s13048-021-00787-z [doi]
PST - epublish
SO  - J Ovarian Res. 2021 Feb 25;14(1):39. doi: 10.1186/s13048-021-00787-z.