PMID- 33633155
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20210311
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 25
TI  - Immunoinformatic based identification of cytotoxic T lymphocyte epitopes from the 
      Indian isolate of SARS-CoV-2.
PG  - 4516
LID - 10.1038/s41598-021-83949-9 [doi]
LID - 4516
AB  - The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has turned into 
      a pandemic with about thirty million confirmed cases worldwide as of September 
      2020. Being an airborne infection, it can be catastrophic to populous countries 
      like India. This study sets to identify potential cytotoxic T lymphocyte (CTL) 
      epitopes in the SARS-CoV-2 Indian isolate which can act as an effective vaccine 
      epitope candidate for the majority of the Indian population. The immunogenicity 
      and the foreignness of the epitopes towards the human body have to be studied to 
      further confirm their candidacy. The top-scoring epitopes were subjected to 
      molecular docking studies to study their interactions with the corresponding 
      human leukocyte antigen (HLA) system. The CTL epitopes were observed to bind at 
      the peptide-binding groove of the corresponding HLA system, indicating their 
      potency as an epitope candidate. The candidacy was further analyzed using 
      sequence conservation studies and molecular dynamics simulation. The identified 
      epitopes can be subjected to further studies for the development of the 
      SARS-CoV-2 vaccine.
FAU - Mulpuru, Viswajit
AU  - Mulpuru V
AD  - Department of Applied Science, Indian Institute of Information Technology 
      Allahabad, Prayagraj, 211012, India.
FAU - Mishra, Nidhi
AU  - Mishra N
AD  - Department of Applied Science, Indian Institute of Information Technology 
      Allahabad, Prayagraj, 211012, India. nidhimishra@iiita.ac.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210225
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - COVID-19/epidemiology/*immunology/prevention & control
MH  - COVID-19 Vaccines/immunology
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - India/epidemiology
MH  - Molecular Docking Simulation
MH  - SARS-CoV-2/*immunology
MH  - Viral Proteins/immunology
PMC - PMC7907102
COIS- The authors declare no competing interests.
EDAT- 2021/02/27 06:00
MHDA- 2021/03/12 06:00
PMCR- 2021/02/25
CRDT- 2021/02/26 05:57
PHST- 2020/04/03 00:00 [received]
PHST- 2021/01/19 00:00 [accepted]
PHST- 2021/02/26 05:57 [entrez]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 10.1038/s41598-021-83949-9 [pii]
AID - 83949 [pii]
AID - 10.1038/s41598-021-83949-9 [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 25;11(1):4516. doi: 10.1038/s41598-021-83949-9.