PMID- 33633270
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 25
TI  - Association of mitochondrial DNA copy number with prevalent and incident type 2 
      diabetes in women: A population-based follow-up study.
PG  - 4608
LID - 10.1038/s41598-021-84132-w [doi]
LID - 4608
AB  - Mitochondrial dysfunction is an important factor of the aging process and may 
      play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is 
      an indirect measure of mitochondrial dysfunction and is associated with type 2 
      diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of 
      developing T2DM is not well-known. We quantified absolute mtDNA-CN in both 
      prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method 
      in a population-based follow-up study of middle aged (50-59 years) Swedish women 
      (n = 2387). The median follow-up period was 17 years. Compared to those who were 
      free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in 
      women who developed T2DM during the follow-up period. Mitochondrial DNA-copy 
      number was also associated with glucose intolerance, systolic blood pressure, 
      smoking status and education. In multivariable Cox regression analysis, lower 
      baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, 
      independent of age, BMI, education, smoking status and physical activity. 
      Moreover, interaction term analysis showed that smoking increased the effect of 
      low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy 
      number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN 
      to predict the future risk of T2DM warrants further investigation.
FAU - Memon, Ashfaque A
AU  - Memon AA
AD  - Wallenberg Laboratory, Center for Primary Health Care Research, Skane University 
      Hospital, Lund University/Region Skane, 6th Floor, Inga Marie Nilsson's gata 53, 
      20502, Malmo, Sweden. ashfaque.memon@med.lu.se.
FAU - Sundquist, Jan
AU  - Sundquist J
AD  - Wallenberg Laboratory, Center for Primary Health Care Research, Skane University 
      Hospital, Lund University/Region Skane, 6th Floor, Inga Marie Nilsson's gata 53, 
      20502, Malmo, Sweden.
FAU - Hedelius, Anna
AU  - Hedelius A
AD  - Wallenberg Laboratory, Center for Primary Health Care Research, Skane University 
      Hospital, Lund University/Region Skane, 6th Floor, Inga Marie Nilsson's gata 53, 
      20502, Malmo, Sweden.
FAU - Palmer, Karolina
AU  - Palmer K
AD  - Wallenberg Laboratory, Center for Primary Health Care Research, Skane University 
      Hospital, Lund University/Region Skane, 6th Floor, Inga Marie Nilsson's gata 53, 
      20502, Malmo, Sweden.
FAU - Wang, Xiao
AU  - Wang X
AD  - Wallenberg Laboratory, Center for Primary Health Care Research, Skane University 
      Hospital, Lund University/Region Skane, 6th Floor, Inga Marie Nilsson's gata 53, 
      20502, Malmo, Sweden.
FAU - Sundquist, Kristina
AU  - Sundquist K
AD  - Wallenberg Laboratory, Center for Primary Health Care Research, Skane University 
      Hospital, Lund University/Region Skane, 6th Floor, Inga Marie Nilsson's gata 53, 
      20502, Malmo, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210225
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - DNA Copy Number Variations/*genetics
MH  - DNA, Mitochondrial/*genetics
MH  - Diabetes Mellitus, Type 2/*epidemiology/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Glucose Intolerance/genetics
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Sweden/epidemiology
PMC - PMC7907271
COIS- The authors declare no competing interests.
EDAT- 2021/02/27 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/02/25
CRDT- 2021/02/26 05:58
PHST- 2020/04/22 00:00 [received]
PHST- 2021/01/29 00:00 [accepted]
PHST- 2021/02/26 05:58 [entrez]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 10.1038/s41598-021-84132-w [pii]
AID - 84132 [pii]
AID - 10.1038/s41598-021-84132-w [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 25;11(1):4608. doi: 10.1038/s41598-021-84132-w.