PMID- 33633309
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 25
TI  - The mitral regurgitation effects of cardiac structure and function in left 
      ventricular noncompaction.
PG  - 4616
LID - 10.1038/s41598-021-84233-6 [doi]
LID - 4616
AB  - This study evaluated the effects of mitral regurgitation (MR) on cardiac 
      structure and function in left ventricular noncompaction (LVNC) patients. The 
      clinical and cardiovascular magnetic resonance (CMR) data for 182 patients with 
      noncompaction or hypertrabeculation from three institutes were retrospectively 
      included. We analyzed the difference in left ventricular geometry, cardiac 
      function between LVNC patients with and without MR. The results showed that 
      patients with MR had a worse New York Heart Association (NYHA) class and a higher 
      incidence of arrhythmia (P < 0.05). MR occurred in 48.2% of LVNC patients. 
      Compared to LVNC patients without MR, the two-dimensional sphericity index, 
      maximum/minimum end-diastolic ratio and longitudinal shortening in LVNC patients 
      with MR were lower (P < 0.05), and the peak longitudinal strain (PLS) of the 
      global and segmental myocardium were obviously reduced (P < 0.05). No significant 
      difference was found in strain in LVNC patients with different degree of MR; end 
      diastolic volume, end systolic volume, and global PLS were statistically 
      associated with MR and NYHA class (P < 0.05), but the non-compacted to compacted 
      myocardium ratio had no significant correlation with them. In conclusion, the 
      presence of MR is common in LVNC patients. LVNC patients with MR feature more 
      severe morphological and functional changes. Hypertrabeculation is not an 
      important factor affecting structure and function at the heart failure stage.
FAU - Zou, Qing
AU  - Zou Q
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, 610041, 
      China.
AD  - Department of Radiology, Deyang People's Hospital, 173# Section 3 Tai Shan Road, 
      Deyang, 618400, Sichuan, China.
FAU - Xu, Rong
AU  - Xu R
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, 610041, 
      China.
FAU - Li, Xiao
AU  - Li X
AD  - Department of Radiology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng 
      District, Beijing, 100730, China.
FAU - Xu, Hua-Yan
AU  - Xu HY
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, 610041, 
      China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AD  - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Wang, Yi-Ning
AU  - Wang YN
AD  - Department of Radiology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences, Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng 
      District, Beijing, 100730, China. wangyining@pumch.cn.
FAU - Fan, Hai-Ming
AU  - Fan HM
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, School of Medicine, Northwest University, Xi'an, 710069, China. 
      fanhm@nwu.edu.cn.
FAU - Guo, Ying-Kun
AU  - Guo YK
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, 610041, 
      China. gykpanda@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210225
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - Cardiomyopathy, Dilated, with Left Ventricular Noncompaction
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/diagnostic imaging/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Heart/diagnostic imaging
MH  - Humans
MH  - Isolated Noncompaction of the Ventricular Myocardium/diagnostic 
      imaging/*physiopathology
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnostic imaging/pathology/*physiopathology
MH  - Myocardium/*pathology
MH  - Retrospective Studies
PMC - PMC7907249
COIS- The authors declare no competing interests.
EDAT- 2021/02/27 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/02/25
CRDT- 2021/02/26 05:59
PHST- 2020/11/30 00:00 [received]
PHST- 2021/02/11 00:00 [accepted]
PHST- 2021/02/26 05:59 [entrez]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/02/25 00:00 [pmc-release]
AID - 10.1038/s41598-021-84233-6 [pii]
AID - 84233 [pii]
AID - 10.1038/s41598-021-84233-6 [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 25;11(1):4616. doi: 10.1038/s41598-021-84233-6.