PMID- 33633561
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210227
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 12
DP  - 2020
TI  - Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases 
      and Glioblastoma.
PG  - 630743
LID - 10.3389/fnagi.2020.630743 [doi]
LID - 630743
AB  - Brain aging is characterized by a time-dependent decline of tissue integrity and 
      function, and it is a major risk for neurodegenerative diseases and brain cancer. 
      Chaperone-mediated autophagy (CMA) is a selective form of autophagy specialized 
      in protein degradation, which is based on the individual translocation of a cargo 
      protein through the lysosomal membrane. Regulation of processes such as 
      proteostasis, cellular energetics, or immune system activity has been associated 
      with CMA, indicating its pivotal role in tissue homeostasis. Since first studies 
      associating Parkinson's disease (PD) to CMA dysfunction, increasing evidence 
      points out that CMA is altered in both physiological and pathological brain 
      aging. In this review article, we summarize the current knowledge regarding the 
      impact of CMA during aging in brain physiopathology, highlighting the role of CMA 
      in neurodegenerative diseases and glioblastoma, the most common and aggressive 
      brain tumor in adults.
CI  - Copyright (c) 2021 Auzmendi-Iriarte and Matheu.
FAU - Auzmendi-Iriarte, Jaione
AU  - Auzmendi-Iriarte J
AD  - Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, 
      Spain.
FAU - Matheu, Ander
AU  - Matheu A
AD  - Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, 
      Spain.
AD  - CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), Madrid, Spain.
AD  - IKERBASQUE, Basque Foundation, Bilbao, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210128
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7901968
OTO - NOTNLM
OT  - CMA
OT  - LAMP2
OT  - glioblastoma
OT  - neurodegenerative diseases
OT  - physiological aging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/27 06:00
MHDA- 2021/02/27 06:01
PMCR- 2020/01/01
CRDT- 2021/02/26 06:02
PHST- 2020/11/18 00:00 [received]
PHST- 2020/12/21 00:00 [accepted]
PHST- 2021/02/26 06:02 [entrez]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/02/27 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2020.630743 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Jan 28;12:630743. doi: 10.3389/fnagi.2020.630743. 
      eCollection 2020.