PMID- 33636691
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20231213
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 136
DP  - 2021 Apr
TI  - Retinal dysfunctions in regular tobacco users: The retina as a window to the 
      reward circuit in addictive disorders.
PG  - 351-357
LID - S0022-3956(21)00090-X [pii]
LID - 10.1016/j.jpsychires.2021.02.023 [doi]
AB  - The nicotine contained in tobacco is a neuromodulator which affects 
      neurotransmission within the brain. The retina is an easy way to study central 
      synaptic transmission dysfunctions in neuropsychiatric disorders. The purpose of 
      this study is to assess the impact of regular tobacco use on retinal function 
      using pattern (PERG), flash (fERG) and multifocal (mfERG) electroretinogram 
      (ERG). We recorded PERG, fERG and mfERG for 24 regular tobacco users and 30 
      healthy non-smoking subjects. The protocol was compliant with International 
      Society for Clinical Electrophysiology of Vision standards. The amplitudes and 
      peak times (PT) of P50, N95 waves (PERG), a-, b- and oscillatory potentials 
      (fERG), and N1, P1, N2 (mfERG) were evaluated. Compared to non-smokers, the 
      results (Mann-Whitney U test, Bonferroni correction) for tobacco users suggested 
      a significant increase of ~ 1 ms in the PT of light-adapted 3.0 fERG b-wave 
      (p = 0.002). Using mfERG, we observed the following increases in tobacco users: 
      in ring 3 for P1 PT of ~1,5 ms and in ring 5 for P1 PT of ~ 1 ms and for N2 PT of 
      ~ 1 ms (p = 0.002, p = 0.002 and p = 0.006). It is our hypothesis that these 
      results reflect the consequences of regular tobacco use on retinal synaptic 
      transmission, and more specifically on dopaminergic and cholinergic transmission. 
      We deduce that the retina may provide a crucial site of investigation for 
      neurotransmission modulation of the reward circuit in regular tobacco users.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Dartois, Mathilde
AU  - Dartois M
AD  - Pole Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand 
      Nancy, Centre Psychotherapique de Nancy, Laxou, France. Electronic address: 
      mathildedartois33@gmail.com.
FAU - Haudiquet, Nicolas
AU  - Haudiquet N
AD  - Pole Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand 
      Nancy, Centre Psychotherapique de Nancy, Laxou, France. Electronic address: 
      haudiquet.n@live.fr.
FAU - Albuisson, Eliane
AU  - Albuisson E
AD  - CHRU-Nancy, DRCI, Departement MPI, Unite de Methodologie, Data management et 
      Statistique UMDS, F-54000, Nancy, France; Universite de Lorraine, Faculte de 
      Medecine, InSciDenS, F-54000, Nancy, France; Universite de Lorraine, CNRS, IECL, 
      F-54000, Nancy, France; Faculte de Medecine, Universite de Lorraine, 
      Vandoeuvre-les-Nancy, France. Electronic address: 
      eliane.albuisson@univ-lorraine.fr.
FAU - Angioi-Duprez, Karine
AU  - Angioi-Duprez K
AD  - Service d'Ophtalmologie, CHRU Nancy, Nancy, France; Faculte de Medecine, 
      Universite de Lorraine, Vandoeuvre-les-Nancy, France. Electronic address: 
      karine.angioi@univ-lorraine.fr.
FAU - Schwan, Raymund
AU  - Schwan R
AD  - Pole Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand 
      Nancy, Centre Psychotherapique de Nancy, Laxou, France; INSERM U1114, Federation 
      de Medecine Translationnelle de Strasbourg, Departement de Psychiatrie, Centre 
      Hospitalier Regional Universitaire de Strasbourg, Strasbourg, France; Faculte de 
      Medecine, Universite de Lorraine, Vandoeuvre-les-Nancy, France. Electronic 
      address: raymund.schwan@univ-lorraine.fr.
FAU - Laprevote, Vincent
AU  - Laprevote V
AD  - Pole Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand 
      Nancy, Centre Psychotherapique de Nancy, Laxou, France; INSERM U1114, Federation 
      de Medecine Translationnelle de Strasbourg, Departement de Psychiatrie, Centre 
      Hospitalier Regional Universitaire de Strasbourg, Strasbourg, France; Faculte de 
      Medecine, Universite de Lorraine, Vandoeuvre-les-Nancy, France. Electronic 
      address: Vincent.laprevote@cpn-laxou.com.
FAU - Schwitzer, Thomas
AU  - Schwitzer T
AD  - Pole Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand 
      Nancy, Centre Psychotherapique de Nancy, Laxou, France; INSERM U1114, Federation 
      de Medecine Translationnelle de Strasbourg, Departement de Psychiatrie, Centre 
      Hospitalier Regional Universitaire de Strasbourg, Strasbourg, France; Faculte de 
      Medecine, Universite de Lorraine, Vandoeuvre-les-Nancy, France. Electronic 
      address: thomas.schwitzer@univ-lorraine.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210213
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Electroretinography
MH  - Humans
MH  - *Retina
MH  - Reward
MH  - Synaptic Transmission
MH  - *Nicotiana
OTO - NOTNLM
OT  - Electroretinogram
OT  - Nicotine
OT  - Retina
OT  - Reward circuit
OT  - Synaptic transmission
OT  - Tobacco
EDAT- 2021/02/27 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/02/26 20:19
PHST- 2020/11/12 00:00 [received]
PHST- 2021/01/20 00:00 [revised]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/02/27 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/02/26 20:19 [entrez]
AID - S0022-3956(21)00090-X [pii]
AID - 10.1016/j.jpsychires.2021.02.023 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2021 Apr;136:351-357. doi: 10.1016/j.jpsychires.2021.02.023. 
      Epub 2021 Feb 13.