PMID- 33637017
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1545-3278 (Electronic)
IS  - 0732-0582 (Linking)
VI  - 39
DP  - 2021 Apr 26
TI  - The Innate Immune Response to Mycobacterium tuberculosis Infection.
PG  - 611-637
LID - 10.1146/annurev-immunol-093019-010426 [doi]
AB  - Infection with Mycobacterium tuberculosis causes >1.5 million deaths worldwide 
      annually. Innate immune cells are the first to encounter M. tuberculosis, and 
      their response dictates the course of infection. Dendritic cells (DCs) activate 
      the adaptive response and determine its characteristics. Macrophages are 
      responsible both for exerting cell-intrinsic antimicrobial control and for 
      initiating and maintaining inflammation. The inflammatory response to M. 
      tuberculosis infection is a double-edged sword. While cytokines such as TNF-alpha and 
      IL-1 are important for protection, either excessive or insufficient cytokine 
      production results in progressive disease. Furthermore, neutrophils-cells 
      normally associated with control of bacterial infection-are emerging as key 
      drivers of a hyperinflammatory response that results in host mortality. The roles 
      of other innate cells, including natural killer cells and innate-like T cells, 
      remain enigmatic. Understanding the nuances of both cell-intrinsic control of 
      infection and regulation of inflammation will be crucial for the successful 
      development of host-targeted therapeutics and vaccines.
FAU - Ravesloot-Chavez, Marietta M
AU  - Ravesloot-Chavez MM
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      California 94720, USA; email: mchavez@berkeley.edu.
FAU - Van Dis, Erik
AU  - Van Dis E
AD  - Division of Immunology and Pathogenesis, Department of Molecular and Cell 
      Biology, University of California, Berkeley, California 94720, USA; email: 
      sastanley@berkeley.edu, vandise@berkeley.edu.
FAU - Stanley, Sarah A
AU  - Stanley SA
AD  - Division of Immunology and Pathogenesis, Department of Molecular and Cell 
      Biology, University of California, Berkeley, California 94720, USA; email: 
      sastanley@berkeley.edu, vandise@berkeley.edu.
AD  - Division of Infectious Diseases and Vaccinology, School of Public Health, 
      University of California, Berkeley, California 94720, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210226
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines
MH  - Humans
MH  - Immunity, Innate
MH  - Macrophages
MH  - *Mycobacterium tuberculosis
MH  - *Tuberculosis
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - PRRs
OT  - cytokines
OT  - inflammation
OT  - innate cells
OT  - innate immunity
OT  - macrophage
OT  - pattern recognition receptors
EDAT- 2021/02/28 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/02/27 05:26
PHST- 2021/02/28 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/02/27 05:26 [entrez]
AID - 10.1146/annurev-immunol-093019-010426 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2021 Apr 26;39:611-637. doi: 
      10.1146/annurev-immunol-093019-010426. Epub 2021 Feb 26.