PMID- 33637848
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20211215
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 26
TI  - Quantitative modeling of multigenerational effects of chronic ionizing radiation 
      using targeted and nontargeted effects.
PG  - 4776
LID - 10.1038/s41598-021-84156-2 [doi]
LID - 4776
AB  - Stress response signals can propagate between cells damaged by targeted effects 
      (TE) of ionizing radiation (e.g. energy depositions and ionizations in the 
      nucleus) and undamaged "bystander" cells, sometimes over long distances. Their 
      consequences, called non-targeted effects (NTE), can substantially contribute to 
      radiation-induced damage (e.g. cell death, genomic instability, carcinogenesis), 
      particularly at low doses/dose rates (e.g. space exploration, some occupational 
      and accidental exposures). In addition to controlled laboratory experiments, 
      analysis of observational data on wild animal and plant populations from areas 
      contaminated by radionuclides can enhance our understanding of radiation 
      responses because such data span wide ranges of dose rates applied over many 
      generations. Here we used a mechanistically-motivated mathematical model of TE 
      and NTE to analyze published embryonic mortality data for plants (Arabidopsis 
      thaliana) and rodents (Clethrionomys glareolus) from the Chernobyl nuclear power 
      plant accident region. Although these species differed strongly in intrinsic 
      radiosensitivities and post-accident radiation exposure magnitudes, model-based 
      analysis suggested that NTE rather than TE dominated the responses of both 
      organisms to protracted low-dose-rate irradiation. TE were predicted to become 
      dominant only above the highest dose rates in the data. These results support the 
      concept of NTE involvement in radiation-induced health risks from chronic 
      radiation exposures.
FAU - Shuryak, Igor
AU  - Shuryak I
AD  - Center for Radiological Research, Columbia University Irving Medical Center, 630 
      West 168th Street, VC-11-234/5, New York, NY, 10032, USA. 
      is144@cumc.columbia.edu.
FAU - Brenner, David J
AU  - Brenner DJ
AD  - Center for Radiological Research, Columbia University Irving Medical Center, 630 
      West 168th Street, VC-11-234/5, New York, NY, 10032, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210226
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - Arabidopsis/*embryology/*radiation effects
MH  - Arvicolinae/*embryology
MH  - *Chernobyl Nuclear Accident
MH  - Embryo Loss/etiology
MH  - Models, Biological
MH  - Radiation Dosage
MH  - Radiation, Ionizing
PMC - PMC7910614
COIS- The authors declare no competing interests.
EDAT- 2021/02/28 06:00
MHDA- 2021/12/16 06:00
PMCR- 2021/02/26
CRDT- 2021/02/27 05:38
PHST- 2020/11/13 00:00 [received]
PHST- 2021/02/12 00:00 [accepted]
PHST- 2021/02/27 05:38 [entrez]
PHST- 2021/02/28 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2021/02/26 00:00 [pmc-release]
AID - 10.1038/s41598-021-84156-2 [pii]
AID - 84156 [pii]
AID - 10.1038/s41598-021-84156-2 [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 26;11(1):4776. doi: 10.1038/s41598-021-84156-2.