PMID- 33637880
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20211215
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 26
TI  - The role of gut microbiota and amino metabolism in the effects of improvement of 
      islet beta-cell function after modified jejunoileal bypass.
PG  - 4809
LID - 10.1038/s41598-021-84355-x [doi]
LID - 4809
AB  - The change in gut microbiota is an important mechanism of the amelioration of 
      type 2 diabetes mellitus (T2DM) after bariatric surgery. Here, we observe that 
      the modified jejunoileal bypass effectively decreases body weight gain, fasting 
      blood glucose, and lipids level in serum; additionally, islet beta-cell function, 
      glucose tolerance, and insulin resistance were markedly ameliorated. The 
      hypoglycemic effect and the improvement in islet beta-cell function depend on the 
      changes in gut microbiota structure. modified jejunoileal bypass increases the 
      abundance of gut Escherichia coli and Ruminococcus gnavus and the levels of serum 
      glycine, histidine, and glutamine in T2DM rats; and decreases the abundance of 
      Prevotella copri and the levels of serum branched chain amino acids, which are 
      significantly related to the improvement of islet beta-cell function in T2DM rats. 
      Our results suggest that amino acid metabolism may contribute to the islet beta-cell 
      function in T2DM rats after modified jejunoileal bypass and that improving gut 
      microbiota composition is a potential therapeutic strategy for T2DM.
FAU - Tan, Cai
AU  - Tan C
AD  - Department of Women's Health, Jiangxi Maternal and Child Health Hospital, 
      Nanchang, 330006, China.
FAU - Zheng, Zhihua
AU  - Zheng Z
AD  - Department of General Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, 330006, China.
AD  - Department of Gastrointestinal Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, 330006, China.
FAU - Wan, Xiaogang
AU  - Wan X
AD  - Department of General Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, 330006, China.
AD  - Department of Gastrointestinal Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, 330006, China.
FAU - Cao, Jiaqing
AU  - Cao J
AD  - Department of General Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, 330006, China.
AD  - Department of Gastrointestinal Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, 330006, China.
FAU - Wei, Ran
AU  - Wei R
AD  - Department of Colorectal Surgery, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, 100021, China.
FAU - Duan, Jinyuan
AU  - Duan J
AD  - Department of General Surgery, The First Affiliated Hospital of Nanchang 
      University, Gastrointestinal Surgical Institute of Nanchang University, Nanchang, 
      330006, China. jinyuan201314@outlook.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210226
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Amino Acids)
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Diabetes Mellitus, Type 2/metabolism/therapy
MH  - *Gastrointestinal Microbiome
MH  - Insulin-Secreting Cells/*metabolism
MH  - *Jejunoileal Bypass/methods
MH  - Male
MH  - Rats
PMC - PMC7910448
COIS- The authors declare no competing interests.
EDAT- 2021/02/28 06:00
MHDA- 2021/12/16 06:00
PMCR- 2021/02/26
CRDT- 2021/02/27 05:38
PHST- 2020/06/11 00:00 [received]
PHST- 2021/02/15 00:00 [accepted]
PHST- 2021/02/27 05:38 [entrez]
PHST- 2021/02/28 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2021/02/26 00:00 [pmc-release]
AID - 10.1038/s41598-021-84355-x [pii]
AID - 84355 [pii]
AID - 10.1038/s41598-021-84355-x [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 26;11(1):4809. doi: 10.1038/s41598-021-84355-x.